Journal of Food Processing & Technology

Comparison of the effects of Lactobacillus brevis and Lactobacillus plantarum on cutaneous wound healing in rats

International Conference and Exhibition on Food Processing & Technology

November 22-24, 2012 Hyderabad International Convention Centre, India

Zahedi F, Heydari Nasrabadi M, Tajabadi Ebrahimi M and Aboutalebi H

Accepted Abstracts: J Food Process Techno

Abstract:

The benefits of probiotic microorganisms have been tested in several studies and they show many positive effects on human health like reduction of serum cholesterol, stimulation of immune system and prevention or treatment of human infections. This study has shown the activity of Lactobacillus brevis and Lactobacillus plantarum isolated from Iranian traditional cheese on cutaneous wound and describes the difference in healing activity between these two Lactobacilli. Some strains of Lactobacillus isolated from traditional dairy products of Iran were investigated for exopolysaccharide (EPS) production using the phenol-sulfuric acid method. L.brevis and L.plantarum were selected because they have high exopolysaccharide (EPS) production. A full-thickness wound (1.5 ? 1.5 cm) was made on the back of each rat (45 rats in 4 groups). Two groups, experimental 1 and experimental 2, were treated by Lactobacillus brevis, and Lactobacillus plantarum that were added to eucerin. A control group was treated with eucerin and a negative-control group, additionally, did not receive anything. On days 1, 3, 7, 14 and 21, the rats were killed and wound tissue samples were collected for histological and statistical studies. The percentage of wound healing and inflammation in the experimental groups on day 21, when compared with the control and negative control groups, were significant (p≤0.05). In contrast to the control and negative-control groups, the number of neutrophils in the experimental groups was reduced in the later phase of wound healing. The current study showed a significant reduction in inflammation and an acceleration of wound healing in wounds treated with Lactobacilli as compared to the control and negative control groups. Further studies are required to develop a mechanism of Lactobacillus brevis and Lactobacillus plantarum during wound healing.

Biography :

Farima Zahedi has completed his MSc at the age of 28 years from Islamic Azad University Damghan Branch. She is the lecturer of Islamic Azad University Parand Branch. She has published more than 20 papers in reputed journals.