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The last decade has seen significant growth in technologies pertaining to molecular biological assays to measure gene expression
profiles. However, evidence suggests that transcriptomic profiling is necessary but not sufficient to characterize biological
system complexity. Therefore, in addition to studying gene expression at the transcriptional level, large-scale proteomic analysis
should be considered as a means to understand the systems and pathways in living organisms. Integrated analysis of global
scale transcriptomic and proteomic data can provide important insights into the metabolic mechanisms underlying complex
biological systems. However, because the relationship between protein abundance and mRNA expression level is complicated by
many cellular and physical processes, sophisticated statistical models need to be developed to capture their relationship. In the
past several years, our group has been using transcriptomic and proteomics data generated from bacterial Desulfovibrio vulgaris
and Shewanella oneidensis to develop novel statistical tools for integrative transcriptomic and proteomic analysis, and results
showed that a better biological interpretation can be achieved by using these statistical methods.
Dr. Zhang is a professor in School of Chemical Engineering and Technology of Tianjin University in China. Prior to joining Tianjin University, Prof.
Zhang was a faculty with Biodesign Institute of Arizona State University, and a Senior Research Scientist II and Senior Principal Investigator at
Microbiology Department with the Pacific Northwest National Laboratory of the U.S. Department of Energy (DOE). Dr. Zhang has broad research
experience in microbial genetics, physiology and ecology, has authored more than 90 peer-reviewed papers. His recent research focuses on
microbial metabolic engineering, applying metatranscriptomics and single-cell transcriptomics for complex microbial community, and developing
computational tools for integrating various post-genomic datasets.
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