alexa Congenital Dyserythropoietic Anaemia: Comparison Of Data At The Childrens Hospital And The Institute Of Child Health, Lahore With The International CDA Registry
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

10th Annual World Congress on Pediatrics,Pediatric Gastroenterology & Nutrition
March 23-25, 2017 Orlando, USA

Saima Farhan
The Children Hospital Lahore, Pakistan
Posters & Accepted Abstracts: Pediat Therapeut
DOI: 10.4172/2161-0665.C1.037
Introduction: The congenital dyserythropoietic anaemias (CDA) comprise a group of rare hereditary disorders of erythropoiesis, characterized by ineffective erythropoiesis as the predominant mechanism of anaemia and by distinct morphological abnormalities of the majority of the erythroblasts in the bone marrow. Whereas, genetic mutations responsible for this disorder have been discovered in European populations; there is still much work to be done in this regard in our part of the world, which could lead to a better management plan for such patients. Objective: The objective of this study was to compare the clinical and laboratory features of CDA patients diagnosed at the Children’s Hospital, Lahore with the International CDA Registry. Materials & Methods: It was a retrospective case series studying data over a 12 year period from 2003-15. Patients diagnosed with CDA on the basis of mild to moderate anaemia, ineffective erythropoiesis and morphological abnormalities of erythroblasts in the bone marrow were included in the study. The parameters studied included age at presentation, gender, severity, skeletal anomalies, number of siblings involved, complete blood count, reticulocyte count, bilirubin levels and bone marrow findings, and these were compared with similar parameters from patients registered with the International CDA Registry. Data analysis was performed using SPSS v22. Results: Significant differences exist between the Pakistani kindred diagnosed with CDA and the international one in terms of age at presentation, severity, skeletal anomalies, no. of siblings involved, haemoglobin levels, RBC count and indices, bilirubin levels and RBC morphological features. However, distribution of the types of CDA, gender and bone marrow findings are almost similar. Conclusion: The clinical and laboratory features of CDA in our patients are significantly different, and more severe, from those registered with the International CDA Registry. As the genetic mutations causing this disease have so far not been mapped in our patients, there could be the possibility of either a different mutation in our population, or an entirely different disorder with bone marrow features similar to CDA.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_mol[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version