alexa Conjugated Glycoenzymes For Targeted And Prophylaxy Action Against Vascular Injuries
ISSN: 2161-1009

Biochemistry & Analytical Biochemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Conference and Exhibition on Biochemical & Molecular Engineering
October 07-08, 2013 Hilton San Antonio Airport, TX, USA

Alexander V. Maksimenko
Accepted Abstracts: Biochem Anal Biochem
DOI: 10.4172/2161-1009.S1.003
Abstract
Vascular protection is one of most actual aims of cardiology nowadays. In these conditions the oxidative stress presents as serious danger factor of cardiovascular system. Antioxidant enzymes are potential means for vascular protection. But they demanded the improvement of their biopharmaceutical properties. For this goal the bienzyme conjugate was obtained by covalent connection one another superoxide dismutase with catalase via endothelial glycocalyx glycosaminoglycans chondroitin sulfate (SOD-CHS-CAT). This SOD-CHS-CAT conjugate possessed vasoprotective activity in respect to platelet interactions, tonus of the ring arterial fragment of rat vessel, normalization of hemodynamic rat and rabbit indices changed with hydrogen peroxide administration as oxidative stress model. The SOD-CHS-CAT conjugate had antiplatelet potential due to its antiaggregation action by means of combined enzyme activities and acquired supramolecular structure. The influence on arterial fragment tonus was equal for SOD and CAT in native and connected in conjugate form. Blood pressure and heart rate were significant and effective normalized with SOD-CHS-CAT conjugate in rats and rabbits (after hydrogen peroxide administration as perturbance stimulus). The ECG has not significant alteration. At the first time we have found in vivo the chronic prophylaxis action for antioxidant bienzyme conjugate. It is important for real development of per oral form of SOD-CHS-CAT conjugate. These results indicate the universal approach to development of enzyme glycoconjugates of medical destination.
Biography

Alexander V. Maksimenko, enzyme engineer of medical preparations, began his work in chemistry at Moscow State University, Chemistry Department where he received a Master of Science degree in 1975 and then Ph.D. in chemistry in 1978. He completed a Doctor of Science in biochemistry and cardiology in 1989 at USSR Cardiology Research Center. He has a long history of work at the Cardiology Center, Moscow beginning in 1978 to present. He is currently the Director of biochemical engineering laboratory, Professor in the Institute of Experimental Cardiology at Russian Cardiology Research-and-Production Complex, Moscow, Russia. He has published more than 200 papers and is the holder of over ten Russian and foreign patents. His research interests are focused on therapeutic enzymes, polymeric drugs, dosage regimen, courses of enzyme therapy, drug targeting and therapeutic compositions.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords