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Conjugated Nitroalkenes In Reactions With Azomethine Imines: Synthesis Of Tetrahydropyrazolo[1,2-a] Pyrazolone Derivatives | 74014
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Conjugated nitroalkenes in reactions with azomethine imines: Synthesis of tetrahydropyrazolo[1,2-a] pyrazolone derivatives

2nd International Conference on PHARMACEUTICAL CHEMISTRY

Nikolay S. Zimnitskiy, Vladislav Yu. Korotaev, Igor B. Kutyashev, Alexey Yu. Barkov and Vyacheslav Ya. Sosnovskikh

Ural Federal University, Russia

Posters & Accepted Abstracts: Med Chem (Los Angeles)

DOI: 10.4172/2161-0444-C1-034

CReaction of (Z)-2-arylidene-5-oxopyrazolidin-2-ium-1-ides 1 with 3-nitro-2-phenyl-2H-chromenes 2 and conjugated (E)-nitropropenes 3 proceed effectively as [3+2] cycloaddition to give products 4 and 5 as single regio- and diastereomers with good yields.The products obtained are of interest due to their potential biological activity. Study of cytotoxity of the described tetrahydropyrazolo[1,2-a]pyrazolone derivatives is in process.

Zimnitskiy N. S. has graduated from the Ural Federal University in 2015 and since then has been working there as a post-graduate student and the junior researcher. As a member of the research group led by prof. Sosnovskikh, he has 3 papers published in peer-reviewed journal within the last year on the topics of unsaturated nitro compounds, heterocyclic compounds and fluoroorganic chemistry.