alexa Controlling TH17 Cells In Inflammation And Carcinogenesis
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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8th European Immunology Conference
June 29-July 01, 2017 Madrid, Spain

Samuel Huber
University Medical Center Hamburg-Eppendorf, Germany
Posters & Accepted Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899-C1-037
Statement of the Problem: The incidence and prevalence of immune mediated inflammatory diseases (IMIDs) are steadily increasing. Unfortunately, most therapies used against these diseases have as of yet palliative character and mostly do not offer a cure. Thus, lifelong treatment using immune-suppressive agents is required in the majority of cases. As a consequence, patients with IMID must live with the side effects of these treatments, such as increased risk of opportunistic infections and of relapsing flares of the disease itself. Furthermore, chronic inflammation, another possible side effect, can promote the development of certain forms of cancer. Therefore, there is major need for new therapies, which can modulate the immune response more specifically. Theoretical Orientation: TH17 cells and their associated cytokines play an important but ambiguous role in these diseases. On one hand they play a key role in chronic inflammatory diseases and carcinogenesis. On the other hand, however TH17 cells and their cytokine products, such as IL-22, also have beneficial properties such as promotion of wound healing and defence against pathogens. This obviously reveals that it is crucial to find out the molecular and cellular mechanisms which physiologically control TH17 cells in order to not just simply deplete them, but rather reset them to their beneficial state. We have indeed already identified several mechanisms, which explain how TH17 cells and their cytokines can be physiologically controlled (Figure 1). Of note, the intestine plays a key role during this regulation. Conclusion & Significance: Our data indicated that TH17 cells can be controlled in the intestine. Our aim is to furthermore understand the involved mechanism.

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