To exploit novel combinations of existing excipients with other substances which exhibit multifunctional role in drug delivery
systems is the need of an hour. Coprocessed Excipients are combinations of two or more excipients that posses performance
advantages that cannot be achieved using a physical admixture of the same combination of excipients. In the present study, the
potential of a novel excipient combination to design gastro retentive drug delivery system (GRDF) was investigated according
to the criteria suggested by EM2 Expert Committee. It is reported that the floating and swellable tablet system is the most
appropriate approach to develop GRDF and should have >15 mm diameter to ensure its gastric retention. Hydroxy propyl methyl
cellulose (HPMC) is conventionally being used in design of such dosage forms but possesses a drawback of time dependant
erosion and hence the chance of its evacuation from the stomach. Low viscosity grade HPMC was coprocessed with the mucilage
isolated from the seeds of Ocimum basilicum in 1:1 proportion to overcome this drawback. This new combination of excipients
was used to prepare gastro retentive tablet. The gastric retention of the dosage form was confirmed by γ scintigraphy study. There
was improved and assured gastric retention of the dosage with immediate buoyancy due to the formation of interpenetrating
polymer network (IPN) which was confirmed by FTIR study.
Sharwaree Rajan Hardikar has completed her M. Pharm from Govt. College of Pharmacy, Karad. She is having 2 years industrial experience and 17
years experience in academics. She has published 15 papers in reputed journals and has filed 04 Indian patents.
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