alexa Countering Tumor Progression By Targeting Of A Driver Of The Epithelial-mesenchymal Transition | 22647
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th World Congress on Cancer Science & Therapy
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Claudia Palena
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.033
Abstract
The epithelial-mesenchymal transition (EMT) constitutes a relevant process during the progression of carcinomas, as it mediates the conversion of stationary, epithelial tumor cells into mesenchymal-like, invasive cancer cells. We recently identified the T-box transcription factor brachyury, a molecule predominantly expressed in human tumors but only rarely expressed in normal adult tissues, as a novel driver of the EMT process in human carcinoma cells. Brachyury was demonstrated to induce the expression of molecules associated with the mesenchymal phenotype, human tumor cell motility and invasiveness in vitro, as well as metastatic propensity in xenograft models. Analysis of expression in multiple human tumor tissues demonstrated a preferential expression of Brachyury in higher stage lung tumors, suggestive of a role of Brachyury in human lung cancer progression. Analysis of breast cancer tissues also revealed expression of Brachyury in primary breast tumor samples as well as in 100% of breast cancer metastatic lesions analyzed by immunohistochemistry. We have now shown a positive correlation between Brachyury expression in epithelial tumor cells and features of tumor stemness, including resistance in response to treatment with various chemotherapeutic agents or radiation. In search for an approach to target tumor cells with high levels of brachyury, we have characterized its immunogenicity and developed brachyury-based cancer vaccine platforms, one of which is currently undergoing Phase I clinical testing. We hypothesize that the eradication of brachyury-expressing tumor cells via immunotherapeutic approaches could be efficient at eliminating tumor cells with invasive/metastatic potential as well as tumor resistance to conventional therapies.
Biography
Claudia Palena is an Investigator and the Head of the Immunoregulation Group in the Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda. She received her PhD degree in Biochemistry from the National University of Rosario, Rosario, Argentina, in 2000, and subsequently completed a Postdoctoral Fellowship in the Laboratory of Tumor Immunology and Biology, NCI. She has published extensively in the area of human tumor antigen discovery and cancer vaccines. Her current research is focused on the development of novel immunotherapeutic approaches aimed at targeting critical events in tumor progression with the ultimate goal of designing vaccine(s) platform(s) and combinatorial therapies for the prevention and/or treatment of metastases in human cancer.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version