alexa C-reactive Protein As An Early Marker Of Opportunistic Infections In HIV
ISSN: 2161-0517

Virology & Mycology
Open Access

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10th World Congress on Virology and Mycology
May 11-12, 2017 Singapore

Nagesh Wadgera and Kala Yadhav M L
Bangalore Medical College and Research Institute, India
Posters & Accepted Abstracts: Virol-mycol
DOI: 10.4172/2161-0517-C1-021
Opportunistic infections account for the majority of death in untreated patients with AIDS. CRP is a highly sensitive marker of infection & inflammation and its level increase with infection. The present study was undertaken among 100 HIV+ patients, at ART center Victoria Hospital Bangalore. With the informed consent of the patient, a generalized proforma was filled up consisting of patient’s clinical presentation and diagnosis. Their CRP level and CD4 count were measured. 56 HIV+ patients were asymptomatic and acted as control giving a negative test for CRP (<6 mg/l), showing no base line rise in CRP. Patients with infectious diagnosis showed a positive test for CRP, while patients on treatment were negative. Among the infectious cases, bacterial infection showed high level of CRP (mean 32 mg/l) compared to viral/fungal infection (mean 9 mg/l). Combinations of opportunistic infections produced a high level of CRP (mean 45 mg/l). A graph of CRP along x-axis and CD4 count along Y-axis were plotted which showed a negative correlation (r=-0.2324, p<0.01 and lzl=2.40). From the graph, the CRP level at which ART can be started is >92.413 mg/l [taking <200 (cells/μl) as the CD4 count at which ART is started]. Patients showing negative test for CRP need not be started with ART, as their CD4 count is found to be approximately 329 cells/μl. CRP level in HIV patients has a prognostic significance and can be used as an early marker of opportunistic infections.


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