alexa
Reach Us +1-504-608-2390
Critical Role For Protein Kinase D In Vascular Endothelial Growth Factor Signaling And Angiogenesis | 7890
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Critical role for protein kinase D in vascular endothelial growth factor signaling and angiogenesis

2nd International Conference on Clinical Research Cardiology, Ophthalmology & Dermatology

Zheng Gen Jin

ScientificTracks Abstracts: J Clinic Experiment Cardiol

DOI: 10.4172/2155-9880.S1.04

Abstract
Trypanosomatids cause deadly diseases in humans. Of the various biochemical pathways in trypanosomatids, glycolysis, has received special attention because of being sequestered in peroxisome like organelles critical for the survival of the parasite. This study focuses on phosphoglycerate kinase (PGK) from Leishmania spp which, exists in two isoforms, the cytoplasmic PGKB and glycosomal PGKC differing in their biochemical properties. Computational analysis predicted the likelihood of a transmembrane (TM) helix only in the glycosomal isoform PGKC-Lmex, of approximate length 20 residues in the 62-residue extension, ending at, arginine residues R471 and R472. From experimental studies using circular dichroism and NMR with deuterated sodium dodecyl sulphate, we find that the transmembrane helix spans residues 448 ?2 to 476. The significance of this observation is discussed in the context of glycosomal transport and susbtrate tunneling
Biography
Top