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Introduction: Curcumin (Cur) is a polyphenol derived from the herbal remedy and dietary spice turmeric. It possesses diverse
anti-inflammatory and anti-cancer properties following oral or topical administration. The buccal delivery of curcumin can be
useful for both systemic and local disease treatments, such as gingivitis, periodontal diseases, oral carcinomas and precancerous
oral lesions. Despite of its high activity, it suffers a limited application due to its low oral bioavailability, poor aqueous solubility,
Aim: Preparation and characterization of curcumin solid lipid nanoparticles with a high loading capacity into a mucoadhesive
gel for buccal application.
Methodology: Curcumin was formulated as nanoparticles using different lipids, namely Gelucire 39/01, Gelucire 50/13,
Precirol, Compritol, and Polaxomer 407 as a surfactant. The SLN were dispersed in a mucoadhesive gel matrix to be applied to
the buccal mucosa. All formulations were evaluated for their content, entrapment efficiency, particle size, in vitro drug dialysis,
ex vivo mucoadhesion test, and ex vivo permeation study using chicken buccal mucosa.
Results: The results showed high entrapment efficiency reaching almost 90 % using Gelucire 50, the loaded gel with Cur-
SLN showed good adhesion property and 25 minutes in vivo residence time. In addition to stability enhancement for the Cur
powder. All formulae did not show any drug permeated however, significant amount of Cur was retained within the mucosal
Conclusion: These results open a room for the pharmaceutical technology to optimize the use of this golden magical powder
to get the best out of it. In addition, the lack of local anti-inflammatory compounds with reduced side effects intensifies the
importance of studying natural products for this purpose.
Heba A Hazzah has completed her masters at the age of 26 years from Alexandria University and currently is working on PhD studies, at Alexandria University faculty of pharmacy. She is an assistant lecturer of pharmaceutics, at the pharmaceutics department, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Egypt