alexa Curcumin Prolongs Graft Survival In Mouse Corneal Allografts | 38096
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products
October 26-28, 2015 Hyderabad, India

Radhakrishna G Pillai
University of Calicut, India
ScientificTracks Abstracts: Nat Prod Chem Res
DOI: 10.4172/2329-6836.C1.007
Abstract
Curcumin is a dietary pigment from the plant Curcuma longa with known antioxidant, anti-neoplastic and anti-inflammatory effects. It is quite safe and has been ingested by people for centuries without significant reports of intoxication. Acute and subchronic toxicology studies showed limited adverse effects. The immunosuppressive and graft protective effects of curcumin were studied in mouse corneal transplant models. Curcumin significantly increased the mean survival time (MST) to 32 days as compared to 14 days among non treated controls. After transplantation there was significant increase in the level of chemokines and cytokines in corneal tissue, which was reduced by an IP treatment with 50 mg/kg curcumin for 7 days. On treatment with curcumin a decrease in the expression level of inducible Nitric Oxide Synthase (iNOS) mRNA and production of nitric oxide by the corneal tissue were also observed. This study for the first time demonstrates the effectiveness of curcumin as a novel immunosuppressant after corneal transplantation. This also reveals the protective effect of curcumin on graft survival.
Biography

Radhakrishna G Pillai has completed his PhD from the Department of Biochemistry, University of Kerala and Post-doctoral studies from School of Medicine, University of California, San Dieg, USA (2000-2006) and Imperial College London (2006-2007). Presently he is working as an Assistant Professor at the Department of Life Sciences, University of Kerala. He has published more than 30 papers in reputed journals and has been serving as an Editorial Board Member of various reputed journals.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version