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Objective: Examined cytokines in serum samples from 80 patients with multiple sclerosis treated with apitherapy in particular
using bee sting therapy.
Methods: Eighty patients with MS, their ages ranged between 26-71 years, were subjected to complete clinical and neurological
history and examination to confirm the diagnosis. All cases were under their regular treatment they were divided into two
main groups, Group I received honey, pollen, royal jelly and propolis and were treated with apiacupuncture 3 times weekly, for
12 months, in addition to their medical treatment, while group II remains on their ordinary medical treatment only. IFN-γ,
interleukin (IL) 1β, IL-4, IL-6, IL-10, tumor necrosis factor alpha (TNFα) were detected. Apiacupuncture was done by bee stings
for regulating the immune system.
Results: Results revealed that 12 patients showed some improvement regarding their defects in gait, bowel control, constipation
and urination, while 28 cases, showed some mild improvement in their movement in bed, and better improvement in bed sores,
sensation, and better motor power, only six cases of them were able to stand for few minutes with support. The level of IFN-γ, (IL)
1β, IL-4, IL-10, TNF-α was significantly elevated in patients in Group II, and no significant differences were found for IL-6 between
the 2 groups of treatment. The mean values of IgE level in both groups of M.S. patients were low but with no statistical significance,
while by the end of the study there were an elevation in the levels of IgE for both groups which was statistically significant.
Conclusion: Although Apitherapy is not a curable therapy in MS, but it can be used to minimize the clinical symptoms of MS
and evaluating responses to specific therapies which can be included among programs of MS therapy. Cytokines in multiple
sclerosis may help to identify mechanisms involved in the pathogenesis of the disease.
Ahmed G Hegaziworked as a Professor of Microbiology & Immunology, National Research Center, Dept. Parasitology, 1997-2000, Chair of Faculty of Medicine, Zagazig University, 1981-1997, part-time Professor and Supervisor of Immunology Section, National Research Center, 1990- up till now. He is also Prof. of Microbiology & Immunology, African Federation of Apiculture Associations (AFAA), 2001- up till now, Standing Commission on Apitherapy (APIMONDIA), 1999 - up till now, Member of Standing Scientific Committee, National Research Center, 1998 –up till now. He was awarded the Excellent Medal of the First Class, 1995, received the Senior Scientist Prize of National Research Center, 1996, and won The Second Best Research Paper award from International Congress of Propolis, Argentina, 2000. He has published in Egyptian Journal of Immunology, 1995, was in the Editorial Board of The Egyptian Association of Immunologists, 1992 –1997, Secretary General, Referee in 37 international journals patents: 4 Patents Educational Activities. He has published 193 articles in national and international scientific journals, 6 books in English and 7 books in Arabic.