alexa Cytotoxic Apo-and Tirucallane-type Triterpenoids From Walsuratrichostemon
ISSN: 2161-0444

Medicinal chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
December 08-10, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Jirapast Sichaem and Santi Tip-Pyang
Posters: Med Chem
DOI: 10.4172/2161-0444.S1.012
Walsuratrichostemon Miq. is a naturally distributed in the evergreen forest throughout Southeast Asia, including countries such as Myanmar, Cambodia and Thailand (in North, Northeast and Southeastern). W. trichostemon is also used in Thai traditional medicine to treat tendon disabilities, as a staunch, for cleaning wounds, as well as a treatment for hemorrhoids. In our continuing search for new anticancer agents from W. trichostemon, we report herein the isolation of six new cytotoxic apoand tirucallane-type triterpenoids, trichostemonate (1), 11, 25-dideacetyltrichostemonate (2), 21, 24, 25-triacetyl-7-deacetyl- 6-hydroxylbrujavanone E (3), 7-deacetylbrujavanone E (4), trichostemonol (5) and trichostemonoate (6) along with seven known triterpenoids, friedelanone (7), β-sitosterol (8), melianone (9), 11α, 20-dihydroxydammar-24-ene-3-one (10), sapelin E acetate (11), grandifolinolenenone (12) and β-sitosterolglucoside(13) were isolated from the roots, leaves, twigs and stem bark of this plant. The structures of all isolated compounds were identified by interpretation of their spectroscopic data, as well as by comparison with those reported in the literature. In addition, the cytotoxicity of all isolated compounds (1-13) against two tumor cell lines (KB and HeLa) was also evaluated.Compounds1 and 10 showed significant cytotoxicity against both KB and HeLa cells (IC503.28 and 0.93, 2.03 and 1.86 μg/mL, respectively) in the invitro tumor cell panel. Compound 5 was displayed the potent cytotoxicity against only HeLa cells (IC50 3.79 μg/mL), while compound 2 showed significant cytotoxicity against KB cells (IC50 3.95μg/mL). Adriamycin was used as the reference substance (IC50 values of 0.05μg/mL for KB cells and 0.17μg/ mL for HeLa cells).
Jirapast Sichaem has completed his PhD at the age of 26 years from Chulalongkorn University. He is doing Postdoctoral studiesin the field of cytotoxic compounds from Thai medicinal plants atNatural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University. He has published more than 20 papers in scientific journals.
image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version