alexa Cytotoxic Apo-and Tirucallane-type Triterpenoids From Walsuratrichostemon
ISSN: 2161-0444

Medicinal chemistry
Open Access

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3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
December 08-10, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Jirapast Sichaem and Santi Tip-Pyang
Posters: Med Chem
DOI: 10.4172/2161-0444.S1.012
Abstract
Walsuratrichostemon Miq. is a naturally distributed in the evergreen forest throughout Southeast Asia, including countries such as Myanmar, Cambodia and Thailand (in North, Northeast and Southeastern). W. trichostemon is also used in Thai traditional medicine to treat tendon disabilities, as a staunch, for cleaning wounds, as well as a treatment for hemorrhoids. In our continuing search for new anticancer agents from W. trichostemon, we report herein the isolation of six new cytotoxic apoand tirucallane-type triterpenoids, trichostemonate (1), 11, 25-dideacetyltrichostemonate (2), 21, 24, 25-triacetyl-7-deacetyl- 6-hydroxylbrujavanone E (3), 7-deacetylbrujavanone E (4), trichostemonol (5) and trichostemonoate (6) along with seven known triterpenoids, friedelanone (7), β-sitosterol (8), melianone (9), 11α, 20-dihydroxydammar-24-ene-3-one (10), sapelin E acetate (11), grandifolinolenenone (12) and β-sitosterolglucoside(13) were isolated from the roots, leaves, twigs and stem bark of this plant. The structures of all isolated compounds were identified by interpretation of their spectroscopic data, as well as by comparison with those reported in the literature. In addition, the cytotoxicity of all isolated compounds (1-13) against two tumor cell lines (KB and HeLa) was also evaluated.Compounds1 and 10 showed significant cytotoxicity against both KB and HeLa cells (IC503.28 and 0.93, 2.03 and 1.86 μg/mL, respectively) in the invitro tumor cell panel. Compound 5 was displayed the potent cytotoxicity against only HeLa cells (IC50 3.79 μg/mL), while compound 2 showed significant cytotoxicity against KB cells (IC50 3.95μg/mL). Adriamycin was used as the reference substance (IC50 values of 0.05μg/mL for KB cells and 0.17μg/ mL for HeLa cells).
Biography
Jirapast Sichaem has completed his PhD at the age of 26 years from Chulalongkorn University. He is doing Postdoctoral studiesin the field of cytotoxic compounds from Thai medicinal plants atNatural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University. He has published more than 20 papers in scientific journals.
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