alexa Defining The Impact Of Immunomodulators And Thrombin Generation Profile In Patients With Active Multiple Myeloma: The Roadmap Study | 71081
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Conference on Hematology and Oncology

Patrick Van Dreden, Loula Papageorgiou, Despina Fotiou, Gueye Mor Seny, Laurent Garderet, Evagelos Terpos, Stella Salta, Theodoros Sergentanis, Athanasios Dimopoulos, Annette K Larsen, Ismail Elalamy and Grigoris T Gerotziafas,
Diagnostica Stago, Asnières-sur-Seine, France
University of Athens, Greece
Hôpital Saint-Antoine, France
Hôpital Tenon (AP-HP), France
Centre de Recherche Saint Antoine - INSERM, France
Posters & Accepted Abstracts: J Blood Disord Transfus
DOI: 10.4172/2155-9864-C1-026
Abstract
Background: Multiple myeloma (MM) and the associated immunomodulatory (IMiD) treatments are associated with risk of vascular complications. Thrombin generation (TG) assessment reflects the equilibrium between procoagulant and anticoagulant activities in the plasma. Aim: We conducted a multicenter study to explore the relationship between stages of MM and alterations of thrombin generation profile. Methods: Patients with MM (n=129) were recruited from July 2014 to December 2016 and stratified to the following groups: 44 newly diagnosed treatment-naïve patients (ND), 33 patients receiving IMiDs (IM), 45 in complete remission (CR) and 7 patients in partial remission on IMiDs (PR/IM). Patients on anticoagulant treatment were excluded from the study. The control group (CG) consisted of 30 healthy age and sex-matched individuals. Samples of platelet-poor plasma (PPP) were assessed for thrombin generation (TG) with the TF 5pM PPP-Reagent® on Calibrated Automated Thrombogram (Stago, France). The upper and lower normal limits (LNL and UNL) were calculated by the mean±2 SD. Results: Patients with ongoing MM (ND, IM, PR/IM) had significantly lower peak, ETP and MRI as compared to the CG. In contrast, patients in CR had peak, ETP, MRI values similar to the CG. Patients with PR had lower ETP and MRI values as compared to the CR group (Table 1). In ND 8% had TG>UNL and 20% had TGUNL and 57% had TGUNL and 33% had TGUNL and 14% had TG
Biography

Patrick Van Dreden is a Head of Clinical Research Department and Prospective Research Manager at Diagnostics Stago. He has Degree of Hemostasis study: Pathogenesis and pharmacology of thrombosis. He is an International Member of Society of Haemostasis and Thrombosis, Member of the European Thrombosis Research Organization, Member of the Mediterranean League against Thromboembolic Diseases, Member of the American Society of Hematology and Member of International Academy of Clinical and Applied Thrombosis/Hemostasis.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

kactakapaniyor.com

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

Taktube

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

sikiş

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

https://www.gaziantepescort.info

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

putlockers

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

seks

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version