alexa Demonstration Of Multivariate Data Analysis For The Development Of Boswellia Serratta Plant Extracts Containing Nanoemulsion
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

3rd International Conference and Exhibition on Biowaivers, Biologics & Biosimilars
October 27-29, 2014 Hyderabad International Convention Centre, Hyderabad, India

Mukesh Gohel, Asha Patel, Tejal Soni and Lal Hingirani
Accepted Abstracts: J Bioanal Biomed
DOI: 10.4172/1948-593X.S1.015
The chemometric techniques have been used to demonstrate the role of nanoemulsion components on release of active herbal principle present in the spray dried Boswellia serratta plant extract. Nanoemulsions were screened for determining the solubility of boswellic acids (BAs) in various systems. Isopropyl myristate, Tween 80 and Transcutol PR were selected as components of the nanoemulsion to draw phase diagrams. Simplex lattice mixture design was applied to optimize the percentual composition of nanoemulsions for the measurement of droplet size and cumulative permeation for topical delivery. The permeability coefficient and droplet size were modelled with set of variables by partial least squares (PLS). Partial least square regression analysis was done through Excel STAT (XL STAT) to influence mixture composition on permeation behavior of drug from the nanoemulsion as calculated models revealed good predictive abilities. The optimized nanoemulsion was incorporated into hydrogelusing Carbopol 940 for ease of topical application. Ex vivo skin permeation and in vivo antiinflammatory study were conducted to evaluate the potential of optimized nanoformulations. The spherical droplet shape was confirmed by TEM analysis. About 3.25 fold increase in flux was seen in case of nanoemulsion, nanogel showed 1.45 fold increase in flux as compared to carbopol gel with highest enhancement ratio 4.57 and 1.59 respectively. Physicochemically stable and non-irritant hydrogel was developed to deliver significant amounts of active herbal principle through skin and showed significant percentage inhibition in rat paw edema. Our study illustrated scientific and statistical evidencefor the potential of developed nanoemulsion as possible alternative to traditional formulations.
image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version