alexa Dermatitis Herpetiformis, Gluten- Sensitive Enteropathy And Sacroilitis - Case Report
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
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Previously: Journal of Pigmentary Disorders

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VI Master Class on Vitiligo and Pigmentary Disorders and Innovative Therapy in Dermatology Symposium, Split, Croatia, May 1-3, 2015

Dubravka ?imić, Kristina Juri?ić, Anita Ostojić, Jasna Zeljko Penavić, Suzana Jelčić Arapović and Ana-Marija Sulić
Conference Proceedings: Pigmentary Disorders 2015
DOI: 10.4172/2376-0427.S11-037
Abstract
Dermatitis herpetiformis is a rare pruritic vesicular disease often related to celiac disease. It is caused by IgA autoantibodies directed against epidermal transglutaminase. Both diseases are the result of an abnormal immune response to gluten antigenes. There is strong HLA association, as 90% of patients are HLA-DQ2 (A1*0501 and B102*), other 10% are HLA-DQ8 (A1*03, B1*03), also other genetic factor are involved. The clinical presentation is caracterised by extremely itchy papules and vesicles, which arise on normal or reddened skin. They tend to be distributed symmetrically and are most often found on the scalp, shoulders, buttocks, elbows and knees. Occasionally we can see sings and symptoms of enteropathy with malapsorption, voluminous loose stools and weight loss. We report a case of a 27-year-old woman with pruritic vesicules on trunk and arms, with histologically confirmed diagnosis of dermatitis herpetiformis. She also had sings of bowel disease with positive specific antibodies for the confirmation of gluten-sensitive enteropathy and complained about strong pain in sacroiliac joints. Diagnosis of sacroilitis was determined by MRI. Also HLA typisation was done. Patient was put on gluten free diet and Dapson which she did not tolerate well. Considering that we did not find any similar cases described in literature we find it important to emphasize this case report as it is not so common.
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