Pharmaceutica Analytica Acta

Design & characterization of controlled release formulations of Emtricitabine alone and in combination with Tenofovir Disoproxil Fumarate

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

A Prameela Rani, G Srikar and Varanasi Satya Narayana Murthy

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Extrusion?spheronization generates multiunit matrix-based particulate systems that produce multiparticulates with spherical shape, good flow properties, low friability, and uniform packing characteristics. Pellets can accommodate high drug loads, and modified drug release can be achieved by incorporating release-modifying agents. The present research was focused mainly to design oral controlled release matrix pellets of Emtricitabine (EMT) alone and in combination with Tenofovir disoproxil fumarate (TDF). EMT & EMT+TDF loaded pellets were developed by the extrusion and spheronization technique and characterized with regard to the micromeritic properties, flow properties, drug content, Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and Stability studies were carried out on the optimized formulation. Invitro drug release studies were performed according to IP. Drug release mechanisms and kinetics were elucidated by zero order, first order, Higuchi and peppas equations which indicate that pellets followed zero order, non fickian diffusion for drug release. Higher concentration of the polymer retards the drug release for longer period of time.