This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Matrix type transdermal drug delivery systems (TDDS) of Hydroxyzine hydrochloride (HHCL) with and without permeation
enhancers were prepared by solvent casting method. Mixture of polymers Eudragit RS100, Eudragit RL100, PVP, HPMC
E15 LV and ethyl cellulose were employed in the preparation of patches. Dibutylphthalate was used as plasticizer. The prepared
patches were evaluated for physicochemical characterization, in vitro and ex vivo diffusion study. In order to reduce the skin barrier
property and to enhance the skin permeation of drug, permeation enhances transcutol and propylene glycol were incorporated in
The central composite design was applied to optimize the best permeation enhancer. Formulations (HhLS3 0t) with Eudragit
RS100, RL100 at 25% transcutol concentration and formulation (HhLS3 -1P) with Eudragit RS100, RL100 at 15% propylene
glycol were found to be the best. Among these two permeation enhancers used, no statistically significant difference (p> 0.05) was
observed between transcutol (25%) and propylene glycol (15%). All the optimized formulations had shown zero order kinetics and
non fickian type of diffusion. No signs of skin-irritation were observed in testing with rabbit.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals