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Design And Development Of Matrix Type Hydroxyzine Hydrochloride Transdermal Patches | 7594
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Design and development of matrix type hydroxyzine hydrochloride transdermal patches

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

K. Venkatasubramanyam

Accepted Abstracts: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.008

Abstract
Matrix type transdermal drug delivery systems (TDDS) of Hydroxyzine hydrochloride (HHCL) with and without permeation enhancers were prepared by solvent casting method. Mixture of polymers Eudragit RS100, Eudragit RL100, PVP, HPMC E15 LV and ethyl cellulose were employed in the preparation of patches. Dibutylphthalate was used as plasticizer. The prepared patches were evaluated for physicochemical characterization, in vitro and ex vivo diffusion study. In order to reduce the skin barrier property and to enhance the skin permeation of drug, permeation enhances transcutol and propylene glycol were incorporated in polymeric films. The central composite design was applied to optimize the best permeation enhancer. Formulations (HhLS3 0t) with Eudragit RS100, RL100 at 25% transcutol concentration and formulation (HhLS3 -1P) with Eudragit RS100, RL100 at 15% propylene glycol were found to be the best. Among these two permeation enhancers used, no statistically significant difference (p> 0.05) was observed between transcutol (25%) and propylene glycol (15%). All the optimized formulations had shown zero order kinetics and non fickian type of diffusion. No signs of skin-irritation were observed in testing with rabbit.
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