Nowadays the challenge is incorporating an existing medicine into a new drug delivery system can significantly improve
its performance in terms of efficacy, safety, and improved patient compliance. The need for delivering drugs to patients
efficiently and with fewer side effects has prompted researchers to engage in the development of new drug delivery systems.
Development of novel drug delivery systems (NDDS) for variety of drugs is very important in order to increase the drug targeting
and effectiveness. This can be done by developing one of NDDS i.e. Niosomal system which is vesicular drug delivery system. In
the present work, Niosomal system of Finasteride was prepared by the incorporation of various classes of non ionic surfactants
(Span 20, Span 80, Tween 20, Tween 80 and Brij35), cholesterol and the drug finasteride. Niosomes were prepared by using lipid
film hydration technique. Different formulations of finasteride were prepared and named as F1, F2, F3, F4 and F5. The prepared
formulations were subjected for entrapment efficiency, vesicular size for the selection of suitable formulation for further studies.
Among the formulations, F1 showed better results as compared with other formulations of Finasteride F2, F3, F4 and F5. The
optimized formulation of Finasteride F1 was used for further studies.
Keywords: Novel drug delivery system, Vesicular drug delivery system, Niosomes, Finasteride, Entrapment efficiency.
M.N. Raviteja is a student of JSS College of Pharmacy, JSS University, Mysore, Karnataka, India. He has completed his B Pharm from JSS College
of Pharmacy, Mysore during the year 2012. Presently he is pursuing M Pharm in Pharmaceutical Quality Assurance in JSS College of Pharmacy,
Mysore. He has presented posters at national level and has attended various National and International Conferences. His current areas of interest
are Quality Assurance, Regulatory Affairs, Quality Management Systems, GMP Auditing.
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