alexa Design And Synthesis Of Novel Benzimidazole, Benzoxazole And Benzothiazole Derivatives Bearing Biologically Active Thiazole, Dihydroquinolone And Thiazolidinone Moieties As A New Class Of Antitumor Agents
ISSN: 2329-6798

Modern Chemistry & Applications
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International Conference on Applied Chemistry
October 17-18, 2016 Houston, USA

John N Phillopes and Phoebe F Lamie
Beni-Suef University, Egypt
ScientificTracks Abstracts: Mod Chem appl
DOI: 10.4172/2329-6798.C1.002
Abstract
Three new series of thiazoles, quinolones and thiazolidinones merged with benzimidazole, benzoxazole and benzothiazole nuclei were synthesized. All the prepared compounds were subjected to IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. Cytotoxic activity of the synthesized compounds was evaluated against two different types of cancer cells, breast (MCF-7) and colon cancer (HCT-116) cell lines. Seven compounds showed potent cytotoxic activity compared with doxorubicin, the reference drug with IC50 between 0.0125-0.0198 μM.
Biography

John N Phillopes has completed his PhD from Beni-Suef University, Egypt and Post-doctoral studies from the same University. He has published many papers in different international journals.

Email: [email protected]

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