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|John N Phillopes and Phoebe F Lamie|
|Beni-Suef University, Egypt|
|ScientificTracks Abstracts: Mod Chem appl|
|Three new series of thiazoles, quinolones and thiazolidinones merged with benzimidazole, benzoxazole and benzothiazole nuclei were synthesized. All the prepared compounds were subjected to IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. Cytotoxic activity of the synthesized compounds was evaluated against two different types of cancer cells, breast (MCF-7) and colon cancer (HCT-116) cell lines. Seven compounds showed potent cytotoxic activity compared with doxorubicin, the reference drug with IC50 between 0.0125-0.0198 μM.|
John N Phillopes has completed his PhD from Beni-Suef University, Egypt and Post-doctoral studies from the same University. He has published many papers in different international journals.
Email: [email protected]
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