alexa Design Of In Vivo Assays For Study Of Transport, Biocompatibility And Toxicity Of Nanoparticles
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Nanotek and Expo
December 3-5, 2012 DoubleTree by Hilton Philadelphia Center City, USA

Kerry J. Lee, Lauren M. Browning, Prakash D. Nallathamby, Tao Huang, Tanvi Desai and X. Nancy Xu
ScientificTracks Abstracts: J Nanomed Nanotechol
DOI: 10.4172/2157-7439.S1.005
Abstract
Nanomaterials possess distinctive physicochemical properties, promising a wide variety of application, ranging from design of high quality consumer products to effective disease diagnosis and therapy. However, these properties may also lead to toxic effects, potentially hindering advances in nanotechnology. This study focuses on the design of model nanomaterials and in vivo assays for study of transport, biocompatibility and toxicity of nanoparticles (NPs). We synthesized and purified spherical silver (Ag) NPs with diameters, ranging from 12 to 95 nm, that are stable (non-aggregated) in egg-water media (1.0 mM NaCl). We developed new imaging approaches to characterize single Ag NPs in zebrafish embryos in real-time at nanometer resolution by measuring their size-dependent localized surface plasmon resonance (LSPR) spectra and scattering intensity using dark-field optical microscopy and spectroscopy (DFOMS). We studied the dependence of transport, biocompatibility and toxicity of Ag NPs in living embryos upon various physicochemical properties (e.g., sizes and charges) of NPs and different developmental stages of embryos in vivo in real-time. Using Ag NPs as optical probes, we continuously imaged nano-environments of developing zebrafish embryos for hours and discovered their transport patterns through the chorion pores, and into the chorion space of the different stages of embryos. We showed that Ag NPs caused a wide variety of deformities and death of embryos, in a concentration (dose) dependent manner and in the surface-charge dependent fashion. This study demonstrates that zebrafish embryos can serve as an effective in vivo assay to characterize the transport, biocompatibility and toxicity of nanomaterials.
Biography
Kerry J. Lee completed her Ph.D. in Biomedical Sciences from Old Dominion University. During her Ph.D. research, she studied the design of in vivo assays to study the transport, biocompatibility, and toxicity of different types of nanoparticles. She has published 8 first-author papers in peer- accepted journals, including ACS Nano, has more than 150 citations, and more than 15 selected presentations and conference abstracts. Kerry is currently assistant professor at South University and has expectations to continue her research using nanoparticle technology to identify and treat diseases
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version