Reach Us +44-1477412632
Design Of Novel Protein Kinase Inhibitors For The Treatment Of Painful Diabetic Neuropathy Using Energy Based Pharmacophore Modeling And Docking Studies | 6154
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Design of novel protein kinase inhibitors for the treatment of painful diabetic neuropathy using energy based pharmacophore modeling and docking studies

3rd World Congress on Diabetes & Metabolism

M. Saketh, Ram Kumar Mishra, D. Sriram and P. Yogeeswari

Posters: J Diabetes Metab

DOI: 10.4172/2155-6156.S1.019

Painful Diabetic Neuropathy (PDN) is an immensely debilitating condition affecting about 20% and 5% of type 2 and type 1 diabetes patients respectively. It involves progressive nerve damage and some of the symptoms like numbness, tingling, hyperalgesia and allodynia greatly affect all areas of patient?s life including mood, sleep, self-worth, independence, ability to work and interpersonal relationships. Currently, the drugs available for PDN offer only symptomatic relief but they do not reverse the nerve damage. Pathogeneses include protein kinase C (PKC) activation, polyol pathway, advanced glycated end products and microangiopathy. In this study, the focus was on PKC, which belongs to the family of protein kinase enzymes which phosphorylate serine/threonine residues. Elevated blood glucose levels via a signaling cascade cause the activation of PKC leading to hyperalgesia and allodynia (through rho kinase activation). PKCβ2 was identified as the PKC isoform involved in PDN. In this study,3 point and 4 point energy based pharmacophores were generated using E-pharmacophore module of Schrodinger suit of softwares. The pharmacophore models were then used for virtual screening and the top ranked hits were docked to the receptor. Top ranked hits were then visually inspected and were shortlisted based on parameters like docking score, fitness score and number of hydrogen bonds. These molecules will be further studied in vitro.
M.Saketh is a final year B.Pharm(Hons.) student presently doing his thesis under Dr. P. Yogeeswari,(Head?Department of Pharmacy) at Birla Institute of Technology & Science-Pilani (BITS-Pilani), Hyderabad Campus since January, 2012.