alexa Design, Synthesis And Testing Of Novel Classes Of Inhibitors Against Metallo-β-lactamases: Towards Drug Leads To Combat Antibiotic Resistance | 24179
ISSN: 2161-0444

Medicinal Chemistry
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing

Yusralina Yusof, Gerhard Schenk and Ross P McGeary
Posters: Med Chem
DOI: 10.4172/2161-0444.S1.012
Abstract
Nowadays, antibiotic resistance incidence is increasing as antibiotics are overprescribed. Since bacteria are able to evolve resistance to new antibiotics (by β-lactamases production) and can transfer genes for antibiotic resistance between unrelated species, standard treatments become ineffective. β-Lactamases are classified into serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs). It is well known that clavulanic acid can effectively inhibit serine β-lactamases (SBLs). Nonetheless, society is in urgent need of metallo-β-lactamases (MBLs) inhibitors as clinically approved inhibitors for MBLs are not yet available. IMP-1, a clinically significant MBL has been reported to cause infections such as pneumonia and wound infections. In this research, novel inhibitors against IMP-1 MBL were designed base on the excellent competitive inhibition properties of L-captopril and D-captopril. Synthesis of the designed IMP-1 inhibitors was completed via three steps reaction (methylation, coupling, and base hydrolysis to remove both methyl ester and thioester). All synthesised compounds including the novel inhibitors and their precursors were tested against IMP-1 enzyme. Potent compounds were selected for further testing to determine the inhibition constant, Ki value.
Biography
Yusralina Yusof has obtained her Bachelor degree from Keio University, Japan in 2005 and Master degree from the same university in 2007. She worked in Universiti Malaysia Sarawak, Malaysia for 5 years before starting PhD research at The University of Queensland, Australia.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

bornova escort

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

https://www.gaziantepescort.info

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version