alexa Determination Of Low-ng/L Level N-dimethynitrasamine In Water By SPE-HPLC MS/MS
ISSN: 2157-7064

Journal of Chromatography & Separation Techniques
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th World Congress on MASS SPECTROMETRY
June 19-21, 2017 London, UK

Dong An and Bin Gu
Fudan University, China
Posters & Accepted Abstracts: J Chromatogr Sep Tech
DOI: 10.4172/2157-7064-C1-026
Abstract
N-nitrosodimethylamine (NDMA), were identified as chloramination byproducts in drinking water. NDMA are known as rodent carcinogens and probable human carcinogens, and so they are considered disinfection byproducts (DBPs) of public health concern. Several analytical techniques have been investigated for analysis of NDMA in water samples, including LC combined with UV detection, chemiluminescence (CL) combined with LC-UV, high-field asymmetric waveform ion-mobility spectrometry (FAIMS)- MS, HPLC-ion exclusion-UV-vis. However, the determination of low-ng/L level NDMA is not accurate. NDMA are typically detected in drinking water at low-ng/L concentrations, demanding highly sensitive analytical techniques to monitor and control them. A solid-phase extraction (SPE) ultra-high-performance-liquid chromatography coupled to a triple quadrupole mass spectrometer (HPLC–MS–MS) equipped with APCI ionization source method was established to determine the concentration of NDMA in water. The experiment results showed that APCI was able to better realize the ionization of NDMA and six other N-nitroamine than ESI. In MRM acquisition mode, ion of m/z 75.1 was determined as precursor ion in which product ion of m/z 58.2 and 43.3 were determined as qualitative and quantitative ions. The relative coefficient of standard curve (1-50μg/L) is 0.996 with pure water as solvents. The recovery rate is more than 80% and the method of determination (MOD) is 1.12-3.11 ng/L when water samples were concentrated by 400 times with coconut active charcoal as adsorbent. This method was applied to determine the concentration of NDMA for source water and treated water. The concentration of source water is lower than LOD. The average concentration of NDMA for treated water in Shanghai water source is 10.65-12.02 ng/L without significantly seasonal change which is probably related to PAM dosage. The successful determination of NDMA by LC MS/MS provides a new method for low-ng/L level NDMA as a supplement.
Biography

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords