alexa Determination Of The Wound Healing Property Of Ficus Elastica (indian Rubber Tree) Leaf Extract In Male Sprague- Dawley Rats On Circular Excision And Linear Incision Model | 14032
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Conference on Pharmacognosy, Phytochemistry & Natural Products
October 21-23, 2013 Radisson Blu Plaza Hotel, Hyderabad, India

Yssa Armeena T. Agapito, Maria Aibel Canaco, Kristine Mari M. Cruz, Patricia Joyce C. de la Pasion, Dominique I. Dela Cruz, Helsa Abigail King, Diana Mae S. Tamayo and Andrea Q. Carigma
Accepted Abstracts: Biochem & Pharmacol
DOI: 10.4172/2167-0501.S1.004
Abstract
Introduction: Ficus elastica has been known to exhibit antibacterial and anti-inflammatory properties that may aid in the wound healing process. Wounds are major concerns for patient and clinician alike because the incidence of severe complications is high and financial resources are limited. The basic objective of the present work was to assess the wound healing activity of the leaf extract of Ficus elastica formulated as 1%, 2%, and 4% ointment. Experimental: Leaves of Ficus elastica were collected and extracted using percolation. Anesthesia using Ketamine (120 mg/ kg) and midazolam intraperitoneally was done prior to incision and excision of wounds to the right dorsal side of 30 male sprague-dawley rats. Groups 1, 2 and 3 were treated with the leaf extract of Ficus elastica in 3 doses, 1%, 2%, and 4% ointment, respectively. The animals of group 4 were topically treated with mupirocin (Bactroban) as positive control while group 5 animals with white petrolatum as negative control. The parameters studied were wound closure, skin tensile strength, and collagen content. The percent wound contraction was based on the comparison of wound healing activity of various formulations. Results and Discussion: One-way ANOVA and Kruskal Wallis revealed no significant difference between the doses of Ficus elastica (p<0.5) which means that the doses are not a factor on the plant?s wound healing property. The leaf extract of Ficus elastica 2% and 4% have significant difference against negative control (white petrolatum) (p<0.05); and positive control (mupirocin) has a significant difference against negative control (white petrolatum) (p<0.05) based on wound tensile strength. There is no significant difference among all the groups (p>0.5) based on wound contraction on the 14th day. The formation of granulation, fibroblast, collagen deposition, epithelialisation and angiogenesis increased in the Ficus elastica leaf extract treated group and Positive control (mupirocin) compared to the negative control (white petrolatum). There was scar formation in negative control (white petrolatum). Positive control (mupirocin) had the the most well-defined stages of wound healing. The extracts were able to increase the breaking strength (incision model), decrease period of epithelialization and increase percentage wound contraction (excision model). Ficus elastica ointment did not cause adverse dermatological effects throughout the duration of the experiment. Conclusion: Ficus elastica leaf extract exhibited wound healing property comparable to the positive control, mupirocin, based on the histopathology and the tensile strength determination. There was no dose-response relationship observed since there is no significant difference among the wound healing activity in each groups given the three doses of the leaf extract. Regardless of the dose, the leaf extract improved the tensile strength of the wound models. The effect of the extract on wound contraction was found to be inconclusive since there was no significant difference observed among all the dose groups. No signs of irritation and other adverse dermatological effects were noted upon administration of Ficus elastica ointment during the 14-day application on the test animals. Ficus elastica leaf extract can be used as a safe, economic and effective pro-healing agents for wound management, enhanced healing and as well as controlling infections.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version