alexa Determination Of The Wound Healing Property Of Ficus Elastica (indian Rubber Tree) Leaf Extract In Male Sprague- Dawley Rats On Circular Excision And Linear Incision Model
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Conference on Pharmacognosy, Phytochemistry & Natural Products
October 21-23, 2013 Radisson Blu Plaza Hotel, Hyderabad, India

Yssa Armeena T. Agapito, Maria Aibel Canaco, Kristine Mari M. Cruz, Patricia Joyce C. de la Pasion, Dominique I. Dela Cruz, Helsa Abigail King, Diana Mae S. Tamayo and Andrea Q. Carigma
Accepted Abstracts: Biochem & Pharmacol
DOI: 10.4172/2167-0501.S1.004
Abstract
Introduction: Ficus elastica has been known to exhibit antibacterial and anti-inflammatory properties that may aid in the wound healing process. Wounds are major concerns for patient and clinician alike because the incidence of severe complications is high and financial resources are limited. The basic objective of the present work was to assess the wound healing activity of the leaf extract of Ficus elastica formulated as 1%, 2%, and 4% ointment. Experimental: Leaves of Ficus elastica were collected and extracted using percolation. Anesthesia using Ketamine (120 mg/ kg) and midazolam intraperitoneally was done prior to incision and excision of wounds to the right dorsal side of 30 male sprague-dawley rats. Groups 1, 2 and 3 were treated with the leaf extract of Ficus elastica in 3 doses, 1%, 2%, and 4% ointment, respectively. The animals of group 4 were topically treated with mupirocin (Bactroban) as positive control while group 5 animals with white petrolatum as negative control. The parameters studied were wound closure, skin tensile strength, and collagen content. The percent wound contraction was based on the comparison of wound healing activity of various formulations. Results and Discussion: One-way ANOVA and Kruskal Wallis revealed no significant difference between the doses of Ficus elastica (p<0.5) which means that the doses are not a factor on the plant?s wound healing property. The leaf extract of Ficus elastica 2% and 4% have significant difference against negative control (white petrolatum) (p<0.05); and positive control (mupirocin) has a significant difference against negative control (white petrolatum) (p<0.05) based on wound tensile strength. There is no significant difference among all the groups (p>0.5) based on wound contraction on the 14th day. The formation of granulation, fibroblast, collagen deposition, epithelialisation and angiogenesis increased in the Ficus elastica leaf extract treated group and Positive control (mupirocin) compared to the negative control (white petrolatum). There was scar formation in negative control (white petrolatum). Positive control (mupirocin) had the the most well-defined stages of wound healing. The extracts were able to increase the breaking strength (incision model), decrease period of epithelialization and increase percentage wound contraction (excision model). Ficus elastica ointment did not cause adverse dermatological effects throughout the duration of the experiment. Conclusion: Ficus elastica leaf extract exhibited wound healing property comparable to the positive control, mupirocin, based on the histopathology and the tensile strength determination. There was no dose-response relationship observed since there is no significant difference among the wound healing activity in each groups given the three doses of the leaf extract. Regardless of the dose, the leaf extract improved the tensile strength of the wound models. The effect of the extract on wound contraction was found to be inconclusive since there was no significant difference observed among all the dose groups. No signs of irritation and other adverse dermatological effects were noted upon administration of Ficus elastica ointment during the 14-day application on the test animals. Ficus elastica leaf extract can be used as a safe, economic and effective pro-healing agents for wound management, enhanced healing and as well as controlling infections.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords