Pharmaceutica Analytica Acta

Development and evaluation of sustained release oral solid dosage form using various polymers and their blends

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

S T Landge1, A V Chandewar1, V M Darvhekar1 and Mohmmed Rageeb2

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Pellet is often referred to as bead-type preparation. In general the beads are prepared by coating drug powder onto preformed cores called non-pareil seeds. The non-pareil seeds are made from slurry of starch, sucrose, and lactose. The use of various amounts of coating solution can provide beads with various coating protection. Blends of GIT-insoluble and GIT soluble polymers are frequently used in coating of sustained released pellets. Ethyl cellulose is used with water soluble polymers HPMC. Upon contact with aqueous media these additives hydrates and potentially leach out from polymeric membrane resulting in more permeable films and increased drug release rate. Pellets were prepared by powder layering method using Diltiazem HCl drug in coating pan. All the batches of pellets were evaluated for the various test i.e., size distribution, friability, moisture content, flow property, content uniformity, water uptake study etc. Final dosage forms were evaluated for weight variation, in-vitro release profile study and drug release kinetic studies as per I.P. /U.S.P. The optimized batch was studied for the stability study. The results revealed that formulation batch F 6 showed drug release rates as per acceptance criteria for USP Test 2 mentioned in USP-NF 2005 for 24 hour dosing of Diltiazem HCl. From this work it can be concluded The result suggest that desired sustained release profile can achieved by the optimized ratio of polymer blends of hydrophobic cellulose polymer Ethyl cellulose and hydrophilic cellulose polymer, HPMC 50 cps for 24 hour dosing pellets.