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A precise, accurate, simple and reliable UV SPECTROPHOTOMETRIC method was developed for a recently marketed new
combination of PANTOPRAZOLE (PAN) and ONDANSETRON (OND). The objective was to subject this new tablet
formulation to Spectrophotometric analysis and arrive at a suitable method for the determination of the drugs therein. The
work was confined to the estimation of content of active ingredients only and was carried out using Simultaneous Equation
Method. Shimadzu UV/Visible double beam spectrophotometer, model 1700 Pharmaspec with 1 cm quartz cells, was used for
Spectrophotometric analysis, using distilled water as solvent. Qualitative and quantitative analysis of the drugs were carried out
in which melting point, UV spectra, λmax and Spiking of drugs was found. Simultaneous Equation method was used for the
estimation of both the drugs. Standard stock solutions of Pantoprazole and Ondansetron were prepared and study of spectra,
selection of scanning range and wavelength was carried out. Lambert Beer Law was studied and also additivity of absorbance
and absorptivity for PAN and OND was studied at selected wavelengths. The absorbance maxima of PAN is 294.5 nm and that
of OND is 310 nm. The method developed was applied to the marketed formulation. The method was validated in terms of
linearity, accuracy, precision, specificity, and ruggedness and was as per ICH guidelines.The developed method for the selected
drugs was applied successfully to both OND and PAN. The results were reproducible and can be adapted for routine quality
control analysis of these drugs in pharmaceutical combined dosage forms.
Priya Prasad at present is pursuing her M. Pharm (Quality Assurance) from Sharad Pawar College of Pharmacy, Nagpur, Maharashtra, India. She
has completed her B. Pharm at the age of 22 from Nagpur University. She has presented papers in many national and international conferences.
She has published 1 paper in international journal. She also has publications in many national souvenirs. She has also won the best research paper
award in one of the national conferences.
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