alexa Development Of A Middle East Respiratory Syndrome Coronavirus Nano Vaccine From Fc4 Fused Spike Protein (eS770)
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

13th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology
July 24-25, 2017 | Rome, Italy

Young Bong Kim, Yeondong Cho, Yoonki Heo, Hee-Jung Lee, Sehyun Kim, Hanul Choi and Jong Kwang Yoon
Konkuk University, Republic of Korea
Posters & Accepted Abstracts: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439-C1-050
Abstract
Middle East respiratory syndrome Coronavirus (MERS-CoV) has emerged as a new pathogen that can transmit between humans as well as animals and humans, causing severe complications and high mortality rates. MERS-CoV continues to spread throughout the pandemic spread around the globe. MERS was first discovered at the end of 2012 and has caused more than 1,800 infections and 650 deaths. Increased MERS cases and no licensed MERS vaccines highlight the need for safe and effective vaccine development for MERS. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry into the cell and is highly immunogenic and induces neutralizing antibodies. In this study, we have expressed the eS1-770 MERS-CoV Spike protein fused with human Fc4 (eS1-770-Fc4) using baculovirus system and purified. Different doses of the eS1-770-Fc4 vaccine candidate were intramuscular injected into mice, and blood samples were collected every 10 days after immunization. The eS1-770-Fc immunized sera showed high titers of MERS-Cov antibodies and neutralizing activity against MERS-CoV. Only 1 ug of eS1-770-Fc4 elicited enough immunogenicity without adjuvant. The eS1-770-Fc could be a potential vaccine candidate. Figure: Schematic diagram of antigens used in MERS-CoV vaccine candidates. Full-length S protein is composed of S1 and S2 fragments. S1 contains the signal peptide (SP) and RBD, whereas S2 contains the transmembrane domain (TM) and cytoplasmic domain (CD). The peptide fused with human IgG Fc domain is designated S-Fc, differentiated by amino acid numbers at the start and endpoint in brackets.
Biography

Young Bong Kim received his Doctorate from Sogang University in Korea and trained at the NIAID/NIH in the United States. Since his appointment as a Professor at Konkuk University in 2003, he has been working on several vaccines against pathogenic viruses such as HIV, MERS-CoV and ZIKA virus.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version