alexa Development Of A Novel Polyherbal Topical Formulation For The Management Of Psoriasis | 60741
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

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International Conference on Psoriasis and Skin Specialists Meeting
December 08-09, 2016 Dallas, USA

Manu Jaggi, Nadav Shraibom, Alka Madaan, Ritu Verma, Neha Gupta, Anika Chaudhary, Gautam Mishra, Pratibha Singh, Sheetal Dobhal and Anu T Singh
Dabur Research Foundation, India
Sirbal Limited, Cyprus
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554.C1.051
Abstract
Psoriasis is a non-infectious and chronic inflammatory skin disorder, characterized by erythematous plaques with red, itchy patches. We have developed a novel aqueous mixture (SIRB-001) consisting of 3 Traditional Chinese Medicine based herbs; Rheum palmatum L. (da huang), Rehmannia glutinosa Libosch. (sheng di huang) and Lonicera Japonica (jin yin hua) (in the ratio 1:1:3), which has demonstrated promising anti-psoriatic activity mediated by anti-proliferative; pro-apoptotic; anti-inflammatory; anti-angiogenic activities in keratinocytes (HaCaT) and efficacy in TPA and IMQ induced animal inflammation models. SIRB-001 based cream and psoriasis kit (shampoo and lotion) were developed and found to be non-irritant. SIRB-001 cream was evaluated for clinical efficacy in an open-label trial in 21 subjects with psoriasis for 8 weeks (twice daily application). After 14, 28, 42 and 56 days, Psoriasis Area and Severity Index (PASI) scores were reduced by 2.9%, 16.6%, 28.7% and 31.5% respectively (p<0.01). SIRB-001 was well tolerated with no local or systemic side effects. Further, safety and efficacy of SIRB-001 psoriasis kit was assessed in a monocentric, open label study in 30 subjects with scalp psoriasis treated for 8 weeks. At day-56, there was a significant reduction (p<0.001) in the mean area of total scalp involved, Investigator's Global Severity Scale (IGSS) and Videodermoscopy Scalp Psoriasis Severity Index (VSCAPSI). SIRB-001 psoriasis kit demonstrated a good safety profile with no incidence of local intolerance. Multiplex analysis in serum samples revealed down regulation (>20%) of IL-5, IL-13, GMCSF, IP-10, MCP-1 and IL-33 after 56 weeks. Hence, SIRB-001 is a highly effective new treatment with a favorable safety profile for management of psoriasis.
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