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Development Of Curcumin Solid Lipid Nanoparticle And Assessment Of Pharmacokinetics And Brain Availability In Wistar Rats | 19783
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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5th World Congress on Bioavailability and Bioequivalence Pharmaceutical R&D Summit

Habibur Rahman
ScientificTracks Abstracts: J Bioequiv Availab
DOI: 10.4172/0975-0851.S1.017
C urcumin, a traditional herb and active ingredient of Curcuma longa (Turmeric) is known for its wide pharmacological actions. Poor bioavailability of curcumin, curtails the therapeutic utility of this potent molecule as drug. Lipid technology is one of the recent approaches developed to enhance bioavailability. In this line, the present study focused on the development of solid lipid nanoparticle (SLN) loaded with curcumin for enhanced bioavailability. Curcumin SLN was prepared using sterotex NF, Gelucire 33/01 and sterotex HM as lipids, Tween 80, Gelucire 44/14, PVP and propylene glycol (PG) as surfactants and co-surfactants. The developed formulations were subjected to various characterisation studies. The results suggest that the formulation prepared using Sterotex HM, Tween 80 and PG (CU5b) to be optimized formulation based on the particle size (127nm), drug entrapment (90.40%) and in vitro drug release (82% at the end of 24 hr) analysis. The optimized curcumin SLN is subjected to pharmacokinetic and brain distribution studies in rats. The drug concentration in plasma and brain was quantified by developed HPLC method. The curcumin SLN showed more than 10 fold increase in bioavailability and dose dependent increase in bioavailability was observed for the developed optimized formulation. Based on the results it is evident that curcumin bioavailability and brain availability was promisingly improved in the form of SLN. The curcumin & SLN curcumin in both the doses was efficient in two compartment model in rat with a fitting weight coefficient of 1/C2. Further and IVIVC should be carried out to establish the curcumin role as drug.
Habibur Rahman MPharm, (PhD), Associate Professor in PSG College of Pharmacy, Coimbatore. He has published & presented several scientific papers in pharmacokientics and bioavailability. His area of research is neuropharmaceutics, pharmacokinetics & PKPD modeling
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