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Development Of Fast Dissolving Oral Film Of Analgesic Drug Markets | 7425
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Development of fast dissolving oral film of analgesic drug markets

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

G. J. Dhumal, D. A. Bhagwat and J. I. D?Souza

Posters: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.007

Abstract
The buccal mucosa has been investigated for local drug therapy and the systemic delivery of therapeutic peptides and other drugs .The tablet dosage forms are more popular but the problems associated with these dosage forms is hepatic first pass metabolism, GI toxicity and enzymatic degradation results in high incidence of non-compliance and ineffective therapy. The fast dissolving oral films overcomes the above problems. After the application of strips to the oromucosal tissue, it instantly wet by saliva, rapidly hydrates and adheres where it rapidly disintegrates and dissolves to release medicament for oromucosal absorption finally leads to quick onset of action particularly to manage pain, allergies, sleep difficulties, and central nervous system disorders. In present work fast dissolving oral films of analgesic drug was formulated by solvent casting technique using polymers like PVP K 30, HPMC, PEG and evaluated for weight variation, film thickness, content uniformity, folding endurance, tensile strength, percent elongation, in-vitro dissolution study, in-vitro drug release study, surface pH. The fast dissolving oral film was successfully formulated to achieve a safe, rapid and effective dosage form with enhanced drug dissolution and rapid analgesic activity.
Biography
Gorakh J. Dhumal doing M. Pharm (Pharmaceutics) in Shivaji University, Kolhapur. He has participated and attended many national and international conferences.
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