Floating matrix tablets were prepared by direct compression method employing polypropylene foam powder (Accurel? MP
1000), karaya gum and chitosan. Tablets were characterized by FT-IR, DSC studies and evaluated for floating lag time,
duration of buoyancy, friability, hardness, thickness, weight variation, swelling studies, drug content, in vitro drug release studies
and in vivo studies. FT- IR and DSC studies showed that there is no interaction between the drug and excipients. The tablets
shows zero floating lag time and remained buoyant for more than 12 h achieving the gastric retention properties. All evaluation
parameters were within the pharmacopoeial limits. The in vitro drug release for losartan potassium was sustained up to 12 h and
release rates were fitted into an empirical equation to compute the diffusion parameter which indicates a super case II- transport
mechanism. X- ray photographs confirms presence of tablet in rabbit stomach for more than 12 h. The studies concluded that
floating matrix tablets could be used as gastro retentive drug delivery systems in view of its floating in stomach.
K.Ramesh is a student of JSS College of Pharmacy, JSS University, Mysore, Karnataka, India. He has completed his B Pharm from JSS College of
Pharmacy, Mysore during the year 2011. Presently he is pursuing M Pharm in Industrial Pharmacy in JSS College of Pharmacy, Mysore. His current
area of interest is in NDDS.
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