alexa
Reach Us +1-217-403-9671
Development Of Floating Matrix Tablet Of Losartan Potassium | 7430
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Development of floating matrix tablet of losartan potassium

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

K. Ramesh, Anil Getyala, H. V. Gangadharappa and N. Vishal Gupta

Posters: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.007

Abstract
Floating matrix tablets were prepared by direct compression method employing polypropylene foam powder (Accurel? MP 1000), karaya gum and chitosan. Tablets were characterized by FT-IR, DSC studies and evaluated for floating lag time, duration of buoyancy, friability, hardness, thickness, weight variation, swelling studies, drug content, in vitro drug release studies and in vivo studies. FT- IR and DSC studies showed that there is no interaction between the drug and excipients. The tablets shows zero floating lag time and remained buoyant for more than 12 h achieving the gastric retention properties. All evaluation parameters were within the pharmacopoeial limits. The in vitro drug release for losartan potassium was sustained up to 12 h and release rates were fitted into an empirical equation to compute the diffusion parameter which indicates a super case II- transport mechanism. X- ray photographs confirms presence of tablet in rabbit stomach for more than 12 h. The studies concluded that floating matrix tablets could be used as gastro retentive drug delivery systems in view of its floating in stomach.
Biography
K.Ramesh is a student of JSS College of Pharmacy, JSS University, Mysore, Karnataka, India. He has completed his B Pharm from JSS College of Pharmacy, Mysore during the year 2011. Presently he is pursuing M Pharm in Industrial Pharmacy in JSS College of Pharmacy, Mysore. His current area of interest is in NDDS.
Relevant Topics
Top