alexa Diabetogenic Gene Expression Analysis Of Butanol Fraction Of Stevia Rebaudiana (bertoni) Leaves In Diabetic Albino Mice
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
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International Conference on Pharmacognosy, Phytochemistry & Natural Products
October 21-23, 2013 Radisson Blu Plaza Hotel, Hyderabad, India

Anand Chaurasia and Murlidhar Kharya
Accepted Abstracts: Biochem & Pharmacol
DOI: 10.4172/2167-0501.S1.004
Abstract
The effect of butanol fraction of ethanol extract of S. rebaudiana on streptozotocin-induced diabetic mice was evaluated the diabetes laden gene expression in diabetic conditions. In streptozotocin induced diabetic mice, two weeks consecutive treatment of butanol fraction (200 mg/kg) was used to evaluate fasting blood glucose, oral glucose tolerance test (OGTT), serum lipid profile, tissues glycogen content, glucose-6-phosphatase and hexokinase enzyme levels in liver and insulin estimation. Subsequently, responsible phytoconstituents for respective activity were identified by HPLC. OGTT determination at 60 min with respect to 30 min level and serum lipid profile exhibited significant reduction (p<0.005) by 38%, 58%, 30% and 30% in TC, LDL,VLDL and TG level respectively with about 75% improvement in HDL in SREEBF treated diabetic mice. Moreover, significant changes in gene expression of Glut-4 in muscle and adipose tissue, AR in kidney, PPAR-α, PPAR-γ and TNF-α in adipose tissues were observed in the experimental animals. SREEBF (200 mg/kg) exhibited significant OGTT and improved serum lipid profile with considerable gene expression of Glut-4, AR, PPAR-α, γ and TNF-α in experimental mice. Study concludes that butanol fraction of ethanol extract of S. rebaudiana did not invoke insulinotropic activity but it has demonstrated antihyperglycemic action. Butanol fraction of ethanol extract of S. rebaudianacan facilitated glucose entry presumably through PPAR-α, γ and Glut-4 receptor into glucose deprived cells, playing vital role in maintaining glucose homeostasis.
Biography
Anand Chaurasia has completed his Ph.D. in Pharmaceutical Sciences, from Dr. H. S. Gour University, Sagar (M.P). Currently, he is serving as a Head, Department of Pharmacology at Sagar Institute of Pharmaceutical Sciences (SIPS). He has published 10 research papers in international journals and presented research papers in international and national conferences and symposia.
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