Dietary modulation of the intestinal immune environment represents a novel approach for enhancing protective responses
against pathogens and inflammatory diseases. We conducted a study to determine the effects of whole dietary rice bran,
which contains numerous bioactive components, on Salmonella fecal shedding. Female129Sv mice were fed 10 and 20% rice bran
diet one week before and during infection for model of Salmonella infection.
Rice bran fed 129Sv mice had significantly reduced Salmonella fecal shedding as compared to control diet fed mice.
Gut microbiome analysis using 454-adaptor pyrosequencing revealed that rice bran modulated the phyla Firmicutes and
Verrucomicrobia. The number of Lactobacillus spp increased in mice (170 fold) after rice bran consumption and retained after
one week of Salmonella infection compared to control diet fed animals. Also, we found that rice bran across diverse rice varieties
differentially inhibited Salmonella fecal shedding and that polyphenols, fatty acids and certain minerals are candidate bioactive
components for correlation with Salmonella fecal shedding.
Dietary rice bran consumption represents a novel means of reducing susceptibility to enteric infection with Salmonella and
potentially other enteric pathogens as well by inducing protective gut mucosal immunity.
Ajay has completed his MS from Haryana Agricultural University in Food Science & Technology and MS in Nutritional Sciences from Florida State
University. Currently, he is pursuing his PhD in Clinical Sciences at College of Veterinary Medicine and Biomedical Sciences, Colorado State
University. His main focus of research is on ?non- specific induction of mucosal immunity against enteric pathogens by dietary rice bran?. He is
working on functional foods for the last 5 years and published research articles as primary and secondary author.
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