alexa
Reach Us +1-217-403-9671
Differences In Bioavailabilities (BA) Determined Using Pharmacokinetic And Pharmacodynamic Parameters Of Endogenous Compounds | 8237
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Differences in Bioavailabilities (BA) determined using pharmacokinetic and pharmacodynamic parameters of endogenous compounds

2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit-2011 and International Conference on Pharmaceutics & Novel Drug Delivery Systems

Chyung S. Cook

ScientificTracks Abstracts: JBB

DOI: 10.4172/2153-2435.10000S4

Abstract
B A may be determined using both plasma concentrations of a drug and its pharmacological eff ects. However, resulting BA can be substantially diff erent as shown in this inhalation insulin study. In a randomized crossover study, 30 healthy subjects (30?1 years) received 10 IU Actrapid ? subcutaneously and 187 IU (6.5 mg) of recombinant human insulin powder by inhalation using the Cyclohaler TM dry powder inhaler under euglycemic glucose clamp conditions. Relative BA following the inhalation administration compared with the subcutaneous dose were 12.0?1.8% and 6.3?0.6% when determined using baseline-adjusted insulin and glucose infusion rate (GIR), respectively. To explain diff erences in BA, a pharmacokinetic- pharmacodynamic model was developed and BAs were predicted at diff erent doses of inhalation insulin with the fi xed 10 IU subcutaneous dose. BA predicted using 3.25 mg inhaled insulin and GIR were 12% and 7.5%, respectively. Without baseline adjustment BA determined with insulin and GIR were similar (11% and 9.0%, respectively). However, a hysteresis plot of GIR vs corresponding insulin concentration showed more potent GIR responses for the same plasma concentrations of insulin following the subcutaneous dose, although the potency of insulin in Actrapid ? and the inhalation powder formulations was the same. Th us, there may be some diff erences in the delivery of insulin to the target site following SC and inhalation administration. In conclusion, the diff erence in BA of insulin and glucose could be explained in part by the non- linear pharmacokinetic-pharmacodynamic relationship. However, there may be other contributing factors (baseline adjustment, diff erent delivery to active site) as well
Biography
Formerly a Senior Director, Dr. Chyung Cook is presently a Principal Scientist in Pharmacokinetics and Bioanalytical Sciences at Baxter Healthcare where his primary responsibility has been directing clinical and pre-clinical PK/PD, drug metabolism and bioanalytical research. Prior to joining Baxter in 2003, Dr. Cook was as a Senior Fellow in Monsanto-Searle and Pharmacia. With his Ph.D. in Medicinal Chemistry he is honored as an AAPS Fellow and has published over 150 peer-reviewed articles and abstracts. His research includes complex PK/PD evaluation, application of drug metabolism in toxicology, food effects and absorption mechanism, BA/BE evaluation, and stereo-selective metabolism
Top