alexa Differential Gene Expression In The Thymus To Establish Low Toxicity Chemotherapeutic Agents
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Clinical & Cellular Immunology
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Philip J Lucas, Kirsten M Williams, Jiun Wang and Ronald E Gress
ScientificTracks Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.017
Abstract
Thymic recovery can be a rate limiting process in full immunological recovery following chemotherapy. Emerging literature suggests that thymic insufficiency may have significant clinical consequences, exacerbating graft-versus-host disease and compromising the graft-versus-leukemia effect. Data have demonstrated that the thymus is damaged following current transplant preparative regimen, with a disproportionate depletion of UEA+ thymic epithelial cells (TEC). Very little is known about the effects of the individual components of such preparative agents. We have established an array of 25 murine genes expressed throughout the thymus, including UEA+ TEC, Ly51+ TEC and all thymocytes. Using quantitative PCR, we were able to use expression levels from this panel of genes to monitor the effects of chemotherapeutic agents on the thymus. To establish feasibility of this model, we first studied the effect of cyclophosphamide, a common agent in many chemotherapeutic regimens. Using a dose of 120 mg/kg x 2, we found significant changes (p<0.05) in 11 of 23 genes in the TEC populations (2 up and 9 down), as well as, 11 genes in the thymocyte population (11 down). Our data suggests that our current panel of thymic expression genes is capable of detecting changes after treatment with potential thymus altering agents.
Biography
Philip J Lucas received his PhD from The George Washington University, Washington, DC in 1991 in Immunology and Molecular Biology and completed his Postdoctoral studies with the Howard Hughes Medical Institute at Washington University School of Medicine in St. Louis, MO. He is currently a Staff Scientist in the Experimental Immunology and Transplantation Branch, NCI, NIH where he studies the effects of stem cell transplantation on thymus.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

agriaquacultur[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords