alexa Dissolution Testing Of Nicotinamide Cocrystals Of A Model BCS-Class-II Drug | 22465
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Biowaivers, Biologics & Biosimilars

Kale Mohana Raghava Srivalli and Brahmeshwar Mishra
ScientificTracks Abstracts: J Bioanal Biomed
DOI: 10.4172/1948-593X.S1.013
Abstract
Pharmaceutical co-crystallization is one of the approaches to enhance the solubility and other physicochemical properties of poorly soluble drugs. Co-crystallization is a pure crystal engineering technique and has been most widely exploited in the past decade. The technique gained popularity because crystalline state is the most preferable form of API on account of its inherent low energy and thermodynamic stability. Nicotinamide or niacinamide is an amide of niacin. It is not only safe and extensively used in man but is also considered the most suitable coformer for cocrystallization when solubility and dissolution enhancement is desired, owing to its hydrophilic nature. The objective of our work was to improve the solubility and dissolution properties of a model BCS-Class-II drug by formulating nicotinamide co-crystal. We evaluated the effect of cocrystallization on the drug solubility and dissolution anticipating a bioavailability enhancement in our future studies. The present study covered preformulation, formulation and in-vitro characterization stages of the prepared formulation. The preformulation phase included UV, FTIR and solubility studies. The nicotinamide cocrystals were prepared by coevaporation method and characterized for solubility and dissolution properties. The results indicated improvement in the solubility and dissolution characteristics of the drug when formulated as nicotinamide cocrystal. The promising batches were further subjected to thermal analysis and crystallographic studies to understand the solid state characteristics.
Biography
Kale Mohana Raghava Srivalli is currently pursuing her PhD in Pharmaceutics from IIT (BHU), Varanasi, India. She received her graduation and post-graduation degrees from Osmania University (affiliated colleges). She has a PG Diploma in Patents law from NALSAR University of Law. She has an excellent academic record to her credit and has published 03 international papers in peer reviewed journals. She authored a research paper and received best poster award in the International Conference on Nano Science & Engineering Applications (ICONSEA-2014), JNTU, Hyderabad. Her major areas of interest are cyclodextrin complexation, cocrystallization, solid dispersion, and nanotechnology. Presently she is engaged in research works related to improvement of physicochemical properties of certain BCS class II drugs.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7