alexa Distinct Effect Of Interleukin 4 And B-cell Activating Factor In Connective Tissue Diseases With Lung Involvement And Idiopathic Pulmonary Fibrosis
ISSN: 1745-7580

Immunome Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th Molecular Immunology and Immunogenetics Congress
March 20-21, 2017 Rome, Italy

Martina Sterclova
Thomayer Hospital, Czech Republic
ScientificTracks Abstracts: J Immunome Res
DOI: 10.4172/1745-7580.C1.011
Abstract
Statement of the Problem: In patients with connective tissue diseases (CTDs) lung involvement may a play important prognostic role. Possible radiologic pattern of lung involvement includes usual interstitial pneumonia, typical also for idiopathic pulmonary fibrosis (IPF). We hypothesize that despite the same radiologic pattern the pathogenetic pathways in IPF and CTD may differ. Methodology & Theoretical Orientation: Sixteen naive CTD patients with lung involvement according to high resolution tomography of the chest and 17 IPF patients were included and underwent serum Ig concentration assessment, flow cytometry of peripheral blood and bronchoscopy with bronchoalveolar lavage (BAL). BAL fluid (BALF) differential cell counts and measurement of IL-4R and BAFF in BALF supernatant were performed. Findings: CTD patients exhibited higher BALF lymphocyte counts (p<0.05) and lower IL-4R concentrations (p<0.05). BAFF concentrations did not significantly differ between groups. Peripheral blood lymphocyte and CD19 counts were higher in IPF patients (p<0.05). Autoantibodies were positive in all CTD and in 8 IPF patients. BAFF concentrations positively correlated with IgM serum concentrations (both in CTD and IPF patients, (p<0.05)). Positive correlations among IL-4R concentrations, serum IgG, IgA and IgM concentrations and CD19 peripheral blood counts (p<0.05) were observed in both groups. Correlations between BAFF and IL-4R BALF concentrations were positive in CTD (p<0.01) and negative in IPF patients (p<0.05). Conclusion & Significance: Our data suggest that the immunologic and molecular markers in peripheral blood and BALF may differ in IPF and CTD patients. We hypothesize that anti-apoptotic effect of IL-4 on B cells may be clinically relevant in IPF patients, while different regulatory pathway may play role in CTD.
Biography

Martina Sterclova has been working since 2004 as a Medical Doctor in the Department of Respiratory Diseases, Thomayer Hospital, Prague. In 2009, she finished her PhD studies in Immunology and Molecular Biology. Her area of interest concerns interstitial lung diseases, namely role of cytokines and chemokines in disease pathogenesis. In 2013, she gained ERS Fellowship and studied bronchoalveolar lavage cell cultures at Comprehensive Pneumology Center, Munich, Germany. She regularly publishes and actively participates in various international conferences on interstitial lung diseases.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords