alexa DNA Methyltransferases: A Novel Approach Towards Understanding Corneal Epithelial Healing Process | 20868
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th International Conference on Clinical & Experimental Ophthalmology

Nikhat Ahmed
Accepted Abstracts: J Clin Exp Ophthalmol
DOI: 10.4172/2155-9570.S1.019
Abstract
This is the first report to show that epigenetic mechanisms are critical regulators of gene expression in ocular disorders. A link between corneal epithelial wound healing and expression of DNMT-1 and DNMT-3b, proposing DNA methylation as one of the underlying regulatory mechanism. The concept of gene de-repression will be critical for furthering our understanding of the complex process of corneal epithelial wound healing. In this study we introduced a new layer of control involving DNMTs that keep these genes silent during unwounded conditions (controls) but active during critical times of wound repair. Identification of such mechanisms could be useful in developing new corneal therapies, especially from the point of drug development. Additionally RNA interference-mediated knock down of DNMT1 in non-migrating controls and DNMT3b in migrating cells results in hypomethylation facilitating cell migration and in the latter case retarded cell migration. The inhibitors of DNA methylation have profound effect on the DNMT1 and 3b. As these genes play a role in extracellular matrix remodelling and cell adhesion, their dysregulation may contribute to development of intact epithelial layer. Our findings suggest that DNA methylation has a key role in regulating expression of genes which are involved in HCEC migration.
Biography
Nikhat Ahmed is a Professor of Biochemistry with a Ph.D. in Neurochemistry from the University of Surrey, England (1981) and post-doctoral from the department of Ophthalmology at School of Medicine, Tuft?s University, Boston, MA. She has worked on the Membrane Proteome Initiatives of AOHUPO and has been has been leading projects of Disease Proteomics, covering the fields of proteomics, biochemistry, molecular and cellular biology both nationally and internationally, since then. She has published more than 50 papers in reputed journals.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7