alexa
Reach Us +1-470-347-1923
Drug Utilization Study Of Anti-epileptic Drugs In Pediatric Population | 19434
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Neurology & Therapeutics

Sengottuvel Viswanathan
Young Research Forum: J Neurol Neurophysiol
DOI: 10.4172/2155-9562.S1.019
Abstract
Background:Epilepsy is achronic neurological morbidity in children. The treatment includes mainly antiepileptic drugs (AEDs). AEDs at times may fail to give complete seizure free interval and also cause adverse drug reactions (ADRs). Our study focused on the prescribing pattern of AEDs for various seizures, treatment outcomes and associated ADRs in children. Objectives: To study the prescribing pattern of AEDs in pediatric outpatient department and to record the seizure control and ADRs. Materials and Methods: Patient characteristics such as age, sex, body weight, diagnosis and comorbid illness were noted. Prescribing pattern of AEDs was assessed according to WHO indicators for drug utilization study. All 200 patients were followed up at 3 months for seizure control and ADRs. Seizure control was recorded, that is, good control if the child was seizure free since prior visit, fair if one seizure and poor for more than one seizure since last visit. ADRs were recorded and documented in a suitably designed form. Results: 200 children-59% boys and 41% girls were enrolled. Among them 61.5% had generalized seizures, 30% complex partial, 5% simple partial, 3% myoclonic and 0.5% absence seizures. The major etiology seen was neurocysticercosis among 30% of children. Regarding treatment with AEDs 87.5% received monotherapy and 12.5% combination therapy. Among monotherapy, 63.5% were prescribed valproate, 20.5% carbamazepine, 2.5% phenytoin. In combination therapy valproate with clobazam (8.5%) and valproate with levetiracetam (1%) were prescribed. In generalized epilepsy 89.5% and 50% of children showed good control with monotherapy and combination therapy respectively. For partial epilepsy 98.2% had good control with monotherapy and 66.7% with combination therapy. ADRs like irritability, sedation, poor school performance were seen higher with combination therapy. Conclusion: The results showed that monotherapy is more effective and safe as compared to combination therapy to treat generalized and partial epilepsy in pediatric population. Also it was found out that valproate was the most commonly prescribed drug for generalized seizures and carbamazepine for partial epilepsy in both monotherapy and combination therapy.
Biography
Sengottuvel Viswanathan completed M.B.B.S from Government medical college Coimbatore and currently a final year MD post graduate student from University College of Medical Sciences Delhi University,India. As a young researcher fascinated towards the challenges in diagnosing and managing various neurlogical disorders. Also involved in infectious disease projects.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version