alexa Early Elevated B-type Natriuretic Peptide Levels Are Associated With Cardiac Dysfunction And Poor Clinical Outcome In Pediatric Septic Patients
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

JOINT EVENT on 11th International Conference on Clinical Pediatrics & 2nd International Conference on Pediatric Surgery
June 29- July 01, 2017 London, UK

Jong-Hau Hsu
Kaohsiung Medical University Hospital, Taiwan
ScientificTracks Abstracts: Pediatr Ther
DOI: 10.4172/2161-0665-C1-039
Abstract
Objective: To determine the B-type natriuretic peptide (BNP) level in pediatric septic patients, and to investigate its association with cardiovascular dysfunction and clinical outcome. Methods: Pediatric patients with sepsis or septic shock were prospectively enrolled in our pediatric intensive care unit (PICU). On day 1 of admission, plasma BNP levels were measured at the time-point of echocardiography. Myocardial dysfunction was defined as left ventricular fractional shortening (FS) < 30%. Inotropic support was quantified by inotropic scores and disease severity was assessed by Pediatric Risk of Mortality (PRISM) III scores. Therafter, associations between BNP levels and clinical parameters were analyzed. Results: There were 94 patients (mean: 5.6 yr, range: 2 mo-17 yr) who were consecutively enrolled in this study. The median BNP level was 127 pg/ml (range: 5 to 4950 pg/ml). BNP levels were correlated with PRISM III (rho=0.36, p=0.001) and C-reactive protein level (r=0.39, p=0.001). The median BNP levels were not only higher in patients with septic shock (n=34) than those with sepsis (n=58) (213 vs. 54 pg/ml, p=0.0004), but also higher in patients with myocardial dysfunction (n=18) than those with preserved myocardial function (n=66) (765 vs. 65 pg/ml, p<0.001). We also found that BNP levels correlated negatively with FS (r=-0.56, p<0.001) and positively with inotropic scores (r=0.34, p=0.04). Most importantly, the median BNP levels were higher in non-survivors (n=13) than survivors (n=81) (367 vs. 106 pg/ml, p=0.003). Conclusion: BNP levels are elevated in pediatric septic patients early in the disease course, and increased levels are associated with cardiovascular dysfunction and worse clinical outcome.
Biography

Jong-Hau Hsu MD, PhD, is a Professor of Pediatrics in Kaohsiung Medical University in Kaohsiung, Taiwan. He is also the Director of Pediatric Cardiology and Pediatric Intensive Care Unit in Kaohsiung Medical University Hospital, and the Vice Director of School of Medicine of Kaohsiung Medical University. As a Pediatric Cardiologist and Intensivist, his research has focused on the role of BNP as a biomarker in pediatric cardiac intensive care and has published 10 articles about BNP since 2007.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords