alexa Effect Of Anakinra On Cirrhotic Cardiomyopathic Rats
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

9th World Congress on Pharmacology
September 04-06, 2017 | Paris, France

Aya Y Gawish, Hebatalla I Ahmed, Medhat I Abd El-Hamid and Azza A Ali
Sinai University, Egypt
Al-Azhar University (Girls), Egypt
Al-Azhar University (Boys), Egypt
Posters & Accepted Abstracts: Biochem Pharmacol (Los Angel)
DOI: 10.4172/2167-0501-C1-007
Abstract
Background: Cirrhotic cardiomyopathy (CCM) is a chronic cardiac dysfunction in cirrhotic patients. It is characterized by hyper dynamic circulation from the peripheral vasodilatation imposed by the neuroendocrine imbalance of hepatic cirrhosis, with increased cardiac output at rest, decreased peripheral vascular resistance and altered diastolic relaxation with electrophysiological abnormalities. The electrical abnormalities include elongation in the QT intervals. Interleukin-1 beta (IL-1 β) is an important proinflammatory cytokine; both IL-1β and tumor necrosis factor α (TNFα) exerted a negative inotropic effect in control papillary muscles through an NO-dependent mechanism, leading to NO production, which played an important role in the pathogenesis of CCM. Aim: Aim of this study is to examine the curative and prophylactic effect of IL-1β blocker (anakinra) on CCM in rats. Methods: CCM was induced by bile duct ligation (BDL) in rats, after 23 days cirrhosis was demonstrated by histopathological studies and serum alkaline phosphatase (ALP), alanine transferase (ALT), aspartate transferase (AST) and cardiomyopathy was confirmed by electrocardiograph, serum brain natriuretic (BNP), glutathione transferase (GSTs), TNFα and tissue cardiac troponin I (cTnI). Anakinra was administered to curative group in day 24 of BDL for five daily doses and it was administered to prophylactic group from day 1 of BDL for 28 daily doses. The data were analyzed by one way ANOVA. Results: After 23 days, serum ALP, AST, ALT, BNP, GSTs, TNFα, tissue cTnI were increased and prolonged QT intervals occurred. After 28 days, in comparison to control CCM group, the curative group 10 mg/kg dose of anakinra significantly decreased in serum ALP, AST, ALT, BNP, GSTs, TNFα, tissue cTnI (p<0.005) and in the prophylactic group 10 mg/kg dose of anakinra, they showed significant decrease (p<0.005), and the restoration of QT intervals occurred in both groups. Conclusion: Targeted blocker of IL-1 β may prove beneficial for reduction and prophylaxis of CCM.
Biography

Aya Y Gawish completed her Graduation at Sinai University in 2011 and MSc in 2015. Her research interest is focus on “Efficacy of natural products to help in improving diabetes mellitus, effect of anti-inflammatory in improving cirrhotic cardiomyopathy, in cardiac diseases and liver diseases

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords