alexa Effect Of Gymnema Sylvestre On Pharmacokinetics And Pharmacodynamics Of Metformin In Diabetic Rats | 14504
ISSN: 2329-6887

Journal of Pharmacovigilance
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference and Exhibition on Pharmacovigilance & Clinical Trials

Shravan Kumar Dholi
Accepted Abstracts: J Pharmacovigilance
DOI: 10.4172/2329-6887.S1.009
Abstract
Diabetes mellitus is a chronic metabolic disorder characterized by raise in blood glucose level. Many physicians prescribe combined pharmacological therapy to obtain adequate blood glucose control which includes combination of thiazolidinediones with sulphonyl ureas or biguanides produce more hypoglycaemia than when given alone. Apart from combinig two or more hypoglcaemic drugs in treatment of diabetis, some patients even physicians recommended use of antidiabetic herbs along with oral hypoglycaemics. Gymnema sylvestre of asclipideaceae family primary has clinical application as an antidiabetic agent. Metformin, an oral antidiabetic drug is the first-line drug of choice for the treatment of type 2 diabetes. This study has been proposed to evaluate the effect of Gymnema sylvestre on pharmacokinetics and pharmacodynamics of metformin in diabetic rats. Administration of both Gymnema extract and metformin to diabetic rats orally causes decrease in the bioavailablity of Metformin significantly (p<0.01) which is proportional to dose of Gymnema sylvestre. When given in combination, there is beneficial glucose level reduction compared to individually treated groups. Results have indicated the negative effect of Gymnema sylvestre on pharmacokinetics but positive effect on pharmacodynamics of metformin. Key Words: Gymnema sylvestre, Metformin, Antidiabetic herbs, Hypoglycaemia
Biography
Shravan kumar dholi has completed M.Pharm., and is pursuing Ph.D. in JNTU. He has published more than 10 papers in national and international journals and presented more than 6 papers in national and international conferences.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7