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|Tianjin Medical University Eye Hospital, China|
|ScientificTracks Abstracts: J Clin Exp Ophthalmol|
|Myopia has the highest incidence in the eye diseases and presents a trend of rapid growth. In China, 78.4% in children who are older than 15 years of age are myopic. While the degree of myopia is deeper, the risk of retinal detachment, retinal neovascularization, cataracts and glaucoma also increased significantly. These complications can cause severe visual loss and irreversible visual impairment. In myopic eye, the structure of sclera was changed, the dry weight of sclera was reduced, the collagen arrangement was disordered, the diameter of the sclera was reduced and the anti-tension ability of sclera was poor. Fortunately, some recent studies have shown that the scleral collagen cross-linking can covalently bind the sclera collagen to enhance the anti-traction ability of sclera, thereby to prevent further extension of axial length. In 2003, Wollensak first reported the safety and effectiveness of using Riboflavin-UVA induced cross-linking to treat progressing keratoconus. Its effect on slowing axial elongation was first documented in 2004. Subsequently, a series of studies was set to test its safety and efficiency in vitro and rabbit sclera. Our research adopts the method of making form deprivation myopia in guinea pigs model and through the Riboflavin-UVA induced collagen cross-linking in the posterior sclera and found that Riboflavin-UVA collagen cross-linking could slow down the experimental myopia in guinea pigs via enhancing the mechanical properties of the sclera and make no obviously damage in the structure of retina and RPE cells.|
Rui-hua Wei has completed her graduation in 1998 with basic Medical degree from the Tianjin Medical University and registered as a Medical Practitioner in Tianjin Medical University Eye Hospital. She has achieved her Master of Clinical Science degree in Ophthalmology Department at National University of Singapore in 2005. She has completed her PhD in Ophthalmology from Tianjin Medical University in 2011. She has completed General Ophthalmology and Refractive Surgery Fellowship at Singapore National Eye Centre (2001-2005) and Cornea Fellowship from the University of Southern California (2009-2010). She has specialized in management of corneal and external eye diseases, dry eye, refractive surgeries and contact lenses. She is also interested in myopia control and management of high myopia related macular disease and complicated cataract.
Email: [email protected]
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