Effect of surfactant on dissolution profile of poorly water soluble acidic drugs

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

Pankaj A. Cheke

Posters: Pharmaceut Reg Affairs

Abstract :

The effects of types of surfactants on the solubilization and dissolution of poorly soluble acidic drugs were compared to identify the most suitable surfactant for conducting an acidic drug dissolution test. sodium lauryl sulfate (SLS) as an anionic surfactant, and polysorbate 80 as a non-ionic surfactant were used in the study. And nimesulide, were selected as model drugs. The dissolution rates of these acidic drugs were substantially enhanced in medium containing Electrostatic interactions between acidic drugs and anionic surfactants were confirmed by measuring UV spectra of each drug. Solubility of drugs in various media and the partition coefficients of drugs into micelles were found to depend on drug characteristics. For acidic drugs, the ability of media containing a cationic surfactant to discriminate rates of dissolution of acidic drugs seemed to be greater than that of media containing other surfactant types.

Biography :

Mr. Pankaj A. Cheke, doing M.Pharm(Pharmaceutics) in Shivaji University, Kolhapur. Presented posters in various national and international conferences.