Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Sanjiv Singh
National Institute of Pharmaceutical Education and Research, India
Posters-Accepted Abstracts: J Pharma Care Health Sys
Diabetes Mellitus is the commonest major metabolic disease and most prevalent diseases worldwide. A relationship was hypothesized between diabetes mellitus and trace elements in contemporary research. There was convincing evidence of role of trace elements in various metabolic processes. Furthermore, insulin action was found to be potentiated by some trace elements like chromium, magnesium, vanadium, zinc, manganese, molybdenum and selenium. In order to compare the three combinations of trace elements for correction of hyperglycaemia, hyperlipidaemia, glycogen content in liver and activities of some important carbohydrate metabolic enzymes in diabetes mellitus, the anti-diabetic effect and acute oral toxicity of a combination of trace elements were assessed. The anti-diabetic activity of the combination of the trace elements was compared with different non-diabetic and streptozotocin-induced diabetic groups for period of 30 days. The significant outcome was observed in management of type 2 diabetes with respect to cholesterol, triglycerides, lipid peroxidation, glutathione, catalase, glycogen, glucose-6-phosphates in liver on treatment with combination of trace elements. Furthermore, protective effect on pancreas injury was observed in animals treated with combination of trace elements. The strong anti-hyperglycemic and anti-hyperlipidemic effect were observed in streptozotocininduced diabetic rats justifies the use of combination of trace elements for the managements of diabetes-related complications.
Email: sanjivpg2006@gmail.com