alexa Effect Of Ursodeoxycholic (UDCA) Acid On Fibrogenolysis Markers In Alcoholic Liver Disease In Man
ISSN: 2167-0889

Journal of Liver
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th International Conference on Hepatology
April 27-28, 2017 Dubai, UAE

Rania Hamed and Hafez Ahmed
Dubai Medical College for Girls, UAE
St. George's, University of London, UK
Posters & Accepted Abstracts: J Liver
DOI: 10.4172/2167-0889-C1-012
Abstract
The fibrogenolysis markers laminin, collagen IV, Collagen VI and collagen XIV are important molecules involved in liver fibrosis that can be measured in the blood to assess liver fibrogenolysis. UDCA is a relatively hydrophilic bile acid that has been shown to be beneficial in cholestatic liver diseases like primary biliary cirrhosis. Alcoholic liver disease (ALD) has many cholestatic features and a beneficial effect for UDCA is therefore hypothesized. We aimed to assess the effect of 6 months UDCA therapy (10 mg/kg, n=24, Childs-Pugh score 21A, 3B) or placebo (n=24, Childs-Pugh score 21A, 3B) on the classic liver function tests and fibrogenolysis markers laminin, collagen IV, Collagen VI and collagen XIV in biopsy confirmed ALD patients. We used carbohydrate deficient transferrin to assess alcohol intake (>6% considered heavy drinking), and measured % UDCA enrichment in total serum bile acids using GC/MS. We observed a statistically significant reduction in γGT (20% reduction) and ALT (10% reduction) from entry values, p<0.05 in both enzymes with UDCA therapy, while ALP and bilirubin were not significantly different in UDCA treated or control groups over the study period. Mean baseline level of laminin was reduced from 26.5±2.1 to 22.2±2.5 ng/ml with UDCA treatment but the difference, which accounts for 16%, was not statistically significant. Collagen IV was reduced from a mean value of 464 + 39.3 to 445 + 40.5 ng/ml, but the change was not statistically significant. A reduction of 12% in collagen VI from 5.1 (+ 0.34) to 4.4 (+ 0.30) was also observed but was not statistically significant. Collagen XIV was largely unchanged at 25.1 (+ 2.3) and 26.0 (+ 2.0) before and after UDCA treatment. These preliminary results are difficult to interpret as the trend of reduction in three of the four fibrogenolysis markers tested was maintained at 3 and 6 months of UDCA therapy, but statistical significance for any of these differences was not obtained perhaps for the relatively small sample studied since the number determined by sample size calculation was difficult to recruit over the study period. A larger clinical trial is needed to further explore UDCA efficacy in the treatment of ALD and how to optimise the selected battery of the fibrogenolysis markers in the assessment of response to therapy, compliance and prognosis.
Biography

Email: Dr.Rania @dmcg.edu

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords