alexa Effectiveness Of Fingolimod In Patients With Relapsing-remitting Multiple Sclerosis In Daily Clinical Practice In Spain: Results From A Multivariate Pool Analysis Called Fingoview
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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11th World Congress on Neurology and Therapeutics
March 27-29, 2017 Madrid, Spain

Jose Meca-Lallana, Guillermo Izquierdo, Celia Oreja, Lucia Forero, Teresa Ayuso, Angel Perez Sempere, Nicolas Herrera, Javier Ricart, Eli Garcia and Irene Sanchez-Vera on behalf of the investigators of the MS NEXT and MS SECOND LINE GATE studies
Servicio de Neurologia. Hospital Universitario Miguel Servet. Zaragoza.
Servicio de Neurologia. Hospital de Virgen de la Arrixaca. Murcia.
Servicio de Neurologia. Hospital Virgen Macarena, Sevilla.
Servicio de Neurologia. Hospital Clinico San Carlos. Madrid.
Servicio de Neurologia. Hospital Universitario Puerta del Mar. Cadiz.
Servicio de Neurologia, Hospital de Navarra. Pamplona
Servicio de Neurologia, Hospital General de Alicante. Alicante
Servicio de Neurologia, Hospital de Burgos. Burgos
Novartis Farmaceutica S.A., Spain
ScientificTracks Abstracts: J Neurol Neurophysiol
DOI: 10.4172/2155-9562.C1.046
Abstract
Introduction: Once-daily Fingolimod (Gilenya®, Novartis Pharma AG) is a sphingosine 1-phosphate receptor modulator approved for relapsing MS treatment. Continuous collection and analysis of real world effectiveness and safety data is the key to making accurate treatment decisions. The objective is to describe basal characteristics and effectiveness of fingolimod in patients with relapsingremitting multiple sclerosis (RRMS) followed for ≥12 months in routine clinical practice in Spain. Methods: Fingoview is a multivariate pool analysis of two observational, retrospective chart reviews, multicenter studies MS Second Line Gate and MS Next, conducted in specialized MS centers in Spain, between November 2014 and December 2015. Pool analysis was prospectively planned. Both studies included patients of both sexes, ≥18 years, diagnosed with RRMS, treated with fingolimod according to SmPC and followed up for ≥12 months after treatment initiation. Results: Fingoview included 988 patients (70 naïve, 252 post-natalizumab, 666 post first-line injectable DMTs), 68.9% female, mean (SD) age: 40.44 (9.1) years. After 1, 2, 3 years of treatment, mean annual relapse rate decreased by 76.5% (mean: 1.19 to 0.28), 82.4% (0.21) and 86.3% (0.16) compared to the year prior to fingolimod (all p<0.0001). At 12 months, 89.6% of patients had stable or improved EDSS which was maintained in 84.4% of patients at 24 months. New/enlarged T2 lesions, gadolinium-enhancing lesions on T1 or radiologically disease free will be discussed. Conclusion: After switching to fingolimod, RRMS had significantly suppressed clinical disease activity and most of the patients have a stable EDSS after one year of treatment.
Biography

Irene Sanchez-Vera completed her PhD in Neuropharmacology from Carlos Haya University Hospital (Malaga, Spain) and has been working as a Postdoctoral Researcher at Carlos Haya University Hospital (Malaga, Spain), Principe Felipe Research Centre (Valencia, Spain), Andalusian Centre of Molecular Biology and Regenerative Medicine (CABIMER, Seville, Spain), Institute de la Vision (Paris, France), University of Valencia (Spain), and Genetic Medicine Institute (Newcastle upon Tyne, UK). Nowadays, she is a Medical Scientific Liaison at Novartis Farmaceutica (Spain). She has publications in reputed international journals in Neuroscience field, and has been serving as Invited Referee in international journals

Email: irene.sanchez_vera@novartis.com

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