alexa Effects Of Chronic Unpredictable Stress On Cognitive And Depressive-like Behaviors Following Experimental Brain Trauma
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

11th World Congress on Neurology and Therapeutics
March 27-29, 2017 Madrid, Spain

Corina O Bondi
University of Pittsburgh, USA
ScientificTracks Abstracts: J Neurol Neurophysiol
DOI: 10.4172/2155-9562.C1.046
Abstract
Traumatic brain injury (TBI) affects 2 million individuals in the United States each year, and many survivors endure cognitive impairments, while also being vulnerable to neuropsychiatric disorders. Clinical and preclinical research has highlighted the importance of chronic stress as a major risk factor for many psychopathological conditions. In the current study, we are assessing clinically-relevant cognitive-behavioral and anxiety-like dimensions sensitive to both TBI and chronic unpredictable stress (CUS). We hypothesized that moderate TBI produced by controlled cortical impact (CCI) injury, as well as CUS exposure will render cognitive impairments in male rats in an attentional set-shifting test (AST), reduced sucrose preference and open field exploration, blunted weight gain, elevated stress hormones and inflammatory markers. Anesthetized adult male rats were subjected to a CCI (2.8 mm cortical tissue deformation) or sham injury over the right parietal cortex. Rats were then randomly assigned to receive CUS (21 days) or 30 sec of handling (CTRL). Upon cessation of stress, rats were tested for perceived state of anxiety (open field test) and anhedonia (preference of 1% sucrose-water versus regular water). At 4 weeks post-surgery, rats were then tested on the AST, which involves a series of increasingly difficult discriminative tasks to obtain food reward. While TBI and CUS alone impaired behavioral flexibility on AST, as expected, the combination group (TBI+CUS) does not seem to negatively impact exploration in the open field, sucrose preference or AST performance (n=8-12/group). Moreover, serum levels of corticosterone (CORT), and inflammatory markers (IL- 1β and TNFα) were paradoxically reduced in the TBI+CUS rats compared to controls, suggesting a putative enhanced resilience in this group. This ongoing project will provide novel outcomes pertaining to cognitive capability, as well as anxiety- and depressive-like symptoms following overlapping chronic stress exposure and the recovery phase of TBI.
Biography

Corina Bondi, PhD, is an Assistant Professor in the Department of Physical Medicine and Rehabilitation and at the Safar Center for Resuscitation Research at the University of Pittsburgh. Her research interests focus on characterizing therapeutic strategies after experimental traumatic brain injury, such as pharmacotherapies and environmental enrichment, for complex cognitive processing deficits and distinct neurobehavioral and neurochemical alterations relevant to psychiatric disorders.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords